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Protein Page:
CDH3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDH3 Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: cell-cell adherens junction; cytoplasm; integral to membrane; plasma membrane
Molecular Function: calcium ion binding
Biological Process: cell adhesion; cell-cell adhesion; hair cycle process; homophilic cell adhesion; keratinization; negative regulation of catagen; negative regulation of transforming growth factor-beta2 production; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of melanin biosynthetic process; positive regulation of monophenol monooxygenase activity; response to drug; retinal homeostasis; visual perception; Wnt receptor signaling pathway through beta-catenin; wound healing
Disease: Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome; Hypotrichosis, Congenital, With Juvenile Macular Dystrophy
Reference #:  P22223 (UniProtKB)
Gene Symbols: CDH3
Molecular weight: 91,418 Da
Basal Isoelectric point: 4.61  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDH3

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S115‑p DWVVAPIsVPENGKG
0 1 S133‑p QRLNQLKsNKDRDtK
0 1 T139‑p KsNKDRDtKIFySIT
0 1 Y143‑p DRDtKIFySITGPGA
0 1 S359‑p TDLDAPNsPAWRATY
0 1 S492‑p WLAMDPDsGQVTAVG
0 1 K682‑ub LLVRKKRkIkEPLLL
0 1 K684‑ub VRKKRkIkEPLLLPE
0 1 T694 LLLPEDDTRDNVFyy
0 6 Y700‑p DTRDNVFyyGEEGGG
0 24 Y701‑p TRDNVFyyGEEGGGE
0 5 Y713‑p GGEEDQDyDITQLHR
0 3 K818‑ub EWGSRFKkLADMyGG
0 28 Y823‑p FKkLADMyGGGEDD_
  mouse

 
F107 EWVMPPIFVPENGKG
S125 QRLNQLKSNKDRGTK
T131 KSNKDRGTKIFYSIT
Y135 DRGTKIFYSITGPGA
S351 TDLDVPNSPAWRATY
S484 WLAVDPDSGQITAAG
K675 LLVRKKRKVKEPLLL
K677 VRKKRKVKEPLLLPE
T687‑p LLLPEDDtRDNVFYY
Y693 DtRDNVFYYGEEGGG
Y694 tRDNVFYYGEEGGGE
Y706 GGEEDQDYDITQLHR
K811 EWGSRFKKLADMYGG
Y816 FKKLADMYGGGEDD_
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