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Protein Page:
KIF11 (human)

KIF11 a cytoskeletal protein that belongs to the kinesin-like protein family. BimC subfamily. Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Plays a role in chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. Phosphorylation regulates its association with the spindle apparatus. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 10q24.1
Cellular Component: cytoplasm; cytosol; kinesin complex; membrane; microtubule; spindle; spindle microtubule; spindle pole
Molecular Function: microtubule motor activity; plus-end-directed microtubule motor activity; protein complex binding; protein kinase binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; chromosome segregation; microtubule-based movement; mitosis; mitotic spindle organization and biogenesis; regulation of mitotic centrosome separation; retrograde vesicle-mediated transport, Golgi to ER; spindle organization and biogenesis
Disease: Microcephaly With Or Without Chorioretinopathy, Lymphedema, Or Mental Retardation
Reference #:  P52732 (UniProtKB)
Alt. Names/Synonyms: EG5; HKSP; KIF11; kinesin family member 11; kinesin-like 1; Kinesin-like protein 1; Kinesin-like protein KIF11; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; KNSL1; thyroid receptor interacting protein 5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5; TRIP5
Gene Symbols: KIF11
Molecular weight: 119,159 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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