Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1. Interacts with PDCD6 in a calcium-dependent manner. Interacts with KLHL12. Abundantly and ubiquitously expressed. Belongs to the WD repeat SEC31 family. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: COPII vesicle coat; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; ER to Golgi transport vesicle; intracellular membrane-bound organelle; perinuclear region of cytoplasm
Molecular Function: calcium-dependent protein binding; protein binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; COPII coating of Golgi vesicle; response to calcium ion
Alt. Names/Synonyms: ABP125; ABP130; DKFZp686N07171; HSPC275; HSPC334; KIAA0905; MGC90305; Protein transport protein Sec31A; protein-transport protein SEC31; SC31A; SEC31 homolog A (S. cerevisiae); SEC31-like 1; SEC31-like protein 1; SEC31-related protein A; SEC31A; SEC31L1; Web1-like protein; yeast Sec31p homolog