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Protein Page:
LSP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LSP1 May play a role in mediating neutrophil activation and chemotaxis. Binds actin. Activated T-lymphocytes. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Actin-binding
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: actin cytoskeleton; membrane; plasma membrane
Molecular Function: actin binding; signal transducer activity
Biological Process: cell motility; cellular defense response; chemotaxis; signal transduction
Reference #:  P33241 (UniProtKB)
Alt. Names/Synonyms: 47 kDa actin binding protein; 47 kDa actin-binding protein; 52 kDa phosphoprotein; F-actin binding and cytoskeleton associated protein; leufactin (leukocyte F-actin binding protein); leukocyte-specific protein 1; LSP1; Lymphocyte-specific antigen WP34; Lymphocyte-specific protein 1; lymphocyte-specific protein pp52; pp52; WP34
Gene Symbols: LSP1
Molecular weight: 37,192 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LSP1

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S252‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S6‑p __MAEASsDPGAEER
0 1 T20‑p REELLGPtAQWsVED
0 3 S24‑p LGPtAQWsVEDEEEA
0 1 - gap
0 6 V55 DEEGGGHVPERPkQE
0 1 K60‑ub GHVPERPkQEMLLSL
0 1 S66 PkQEMLLSLkPSEAP
0 23 K68‑ub QEMLLSLkPSEAPEL
0 2 P69 EMLLSLkPSEAPELD
0 1 S85 DEGFGDWSQRPEQRQ
0 1 H94 RPEQRQQHEGAQGAL
0 1 S103 GAQGALDSGEPPQCR
0 1 P107 ALDSGEPPQCRsPEG
0 6 S111‑p GEPPQCRsPEGEQED
0 2 Y125‑p DRPGLHAyEKEDsDE
0 5 S130‑p HAyEKEDsDEVHLEE
0 2 S139‑p EVHLEELsLsKEGPG
0 4 S141‑p HLEELsLsKEGPGPE
0 4 N154 PEDTVQDNLGAAGAE
0 28 T175‑p QKCQQPRtPsPLVLE
0 30 S177‑p CQQPRtPsPLVLEGt
0 9 T184‑p sPLVLEGtIEQssPP
0 7 S188‑p LEGtIEQssPPLsPt
0 25 S189‑p EGtIEQssPPLsPtt
0 21 S193‑p EQssPPLsPttKLID
0 3 T195‑p ssPPLsPttKLIDRt
0 7 T196‑p sPPLsPttKLIDRtE
0 1 T202‑p ttKLIDRtEsLNRsI
1 12 S204‑p KLIDRtEsLNRsIEK
0 2 S208‑p RtEsLNRsIEKSNSV
0 5 S218‑p KSNSVKKsQPDLPIS
0 1 K226‑ub QPDLPISkIDQWLEQ
0 9 Y234‑p IDQWLEQytQAIETA
0 1 T235‑p DQWLEQytQAIETAG
0 4 T244‑p AIETAGRtPKLARQA
0 7 A248 AGRtPKLARQAsIEL
2 201 S252‑p PKLARQAsIELPsMA
0 5 S257‑p QAsIELPsMAVAsTK
0 2 S262‑p LPsMAVAsTKsRWEt
0 1 S265‑p MAVAsTKsRWEtGEV
0 1 T269‑p sTKsRWEtGEVQAQS
0 1 S282 QSAAKTPSCKDIVAG
0 2 K300 KKSLWEQKGGSKTSS
0 2 K310 SKTSSTIKSTPSGKR
0 1 K319 TPSGKRYKFVAtGHG
0 2 T323‑p KRYKFVAtGHGkyEK
0 2 K327‑ac FVAtGHGkyEKVLVE
0 14 Y328‑p VAtGHGkyEKVLVEG
  LSP1 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
S4 ____MLLSLKPSEAP
K6 __MLLSLKPSEAPEL
P7 _MLLSLKPSEAPELD
S23 DEGFGDWSQRPEQRQ
H32 RPEQRQQHEGAQGAL
S41 GAQGALDSGEPPQCR
P45 ALDSGEPPQCRSPEG
S49 GEPPQCRSPEGEQED
Y63 DRPGLHAYEKEDSDE
S68 HAYEKEDSDEVHLEE
S77 EVHLEELSLSKEGPG
S79 HLEELSLSKEGPGPE
N92 PEDTVQDNLGAAGAE
T113 QKCQQPRTPSPLVLE
S115 CQQPRTPSPLVLEGT
T122 SPLVLEGTIEQSSPP
S126 LEGTIEQSSPPLSPT
S127 EGTIEQSSPPLSPTT
S131 EQSSPPLSPTTKLID
T133 SSPPLSPTTKLIDRT
T134 SPPLSPTTKLIDRTE
T140 TTKLIDRTESLNRSI
S142 KLIDRTESLNRSIEK
S146 RTESLNRSIEKSNSV
S156 KSNSVKKSQPDLPIS
K164 QPDLPISKIDQWLEQ
Y172 IDQWLEQYTQAIETA
T173 DQWLEQYTQAIETAG
T182 AIETAGRTPKLARQA
A186 AGRTPKLARQASIEL
S190 PKLARQASIELPSMA
S195 QASIELPSMAVASTK
S200 LPSMAVASTKSRWET
S203 MAVASTKSRWETGEV
T207 STKSRWETGEVQAQS
S220 QSAAKTPSCKDIVAG
K238 KKSLWEQKGGSKTSS
K248 SKTSSTIKSTPSGKR
K257 TPSGKRYKFVATGHG
T261 KRYKFVATGHGKYEK
K265 FVATGHGKYEKVLVE
Y266 VATGHGKYEKVLVEG
  LSP1 iso3  
- gap
T148 TNCSPRPTAQWSVED
S152 PRPTAQWSVEDEEEA
- gap
V183 DEEGGGHVPERPKQE
K188 GHVPERPKQEMLLSL
S194 PKQEMLLSLKPSEAP
K196 QEMLLSLKPSEAPEL
P197 EMLLSLKPSEAPELD
S213 DEGFGDWSQRPEQRQ
H222 RPEQRQQHEGAQGAL
S231 GAQGALDSGEPPQCR
P235 ALDSGEPPQCRSPEG
S239 GEPPQCRSPEGEQED
Y253 DRPGLHAYEKEDSDE
S258 HAYEKEDSDEVHLEE
S267 EVHLEELSLSKEGPG
S269 HLEELSLSKEGPGPE
N282 PEDTVQDNLGAAGAE
T303 QKCQQPRTPSPLVLE
S305 CQQPRTPSPLVLEGT
T312 SPLVLEGTIEQSSPP
S316 LEGTIEQSSPPLSPT
S317 EGTIEQSSPPLSPTT
S321 EQSSPPLSPTTKLID
T323 SSPPLSPTTKLIDRT
T324 SPPLSPTTKLIDRTE
T330 TTKLIDRTESLNRSI
S332 KLIDRTESLNRSIEK
S336 RTESLNRSIEKSNSV
S346 KSNSVKKSQPDLPIS
K354 QPDLPISKIDQWLEQ
Y362 IDQWLEQYTQAIETA
T363 DQWLEQYTQAIETAG
T372 AIETAGRTPKLARQA
A376 AGRTPKLARQASIEL
S380 PKLARQASIELPSMA
S385 QASIELPSMAVASTK
S390 LPSMAVASTKSRWET
S393 MAVASTKSRWETGEV
T397 STKSRWETGEVQAQS
S410 QSAAKTPSCKDIVAG
K428 KKSLWEQKGGSKTSS
K438 SKTSSTIKSTPSGKR
K447 TPSGKRYKFVATGHG
T451 KRYKFVATGHGKYEK
K455 FVATGHGKYEKVLVE
Y456 VATGHGKYEKVLVEG
  mouse

► Hide Isoforms
 
I6 __MAEAAIDPRCEEQ
T25 AEDSEGLTTQWREED
R29 EGLTTQWREEDEEEA
K54 RQLQDQDKDKEDDGG
S63‑p KEDDGGHsLEQPGQQ
G68 GHsLEQPGQQTLIsL
S74‑p PGQQTLIsLKsSELD
K76 QQTLIsLKsSELDED
S77‑p QTLIsLKsSELDEDE
S90‑p DEGFGDWsQKPEPRQ
F99 KPEPRQQFWGNEGTA
T109 NEGTAEGTEPSQSER
S112 TAEGTEPSQSERPEE
R116 TEPSQSERPEEKQTE
- gap
Q128 QTEESSHQAKVHLEE
S136‑p AKVHLEEsNLsYREP
S139‑p HLEEsNLsYREPDPE
S152‑p PEDAVGGsGEAEEHL
T166‑p LIRHQVRtPsPLALE
S168‑p RHQVRtPsPLALEDt
T175‑p sPLALEDtVELssPP
S179‑p LEDtVELssPPLsPt
S180‑p EDtVELssPPLsPtt
S184‑p ELssPPLsPttKLAD
T186‑p ssPPLsPttKLADRT
T187‑p sPPLsPttKLADRTE
T193 ttKLADRTEsLNRsI
S195‑p KLADRTEsLNRsIKK
S199‑p RTEsLNRsIKKSNSV
S209‑p KSNSVKKsQPTLPIS
T217 QPTLPISTIDERLQQ
Y225‑p IDERLQQyTQATESS
T226 DERLQQyTQATESSG
T235‑p ATESSGRtPKLsRQP
S239‑p SGRtPKLsRQPsIEL
S243‑p PKLsRQPsIELPsMA
S248‑p QPsIELPsMAVASTK
S253 LPsMAVASTKTLWET
T256 MAVASTKTLWETGEV
T260 STKTLWETGEVQSQS
S273‑p QSASKTPsCQDIVAG
K291‑ac KKSLWEQkGGSKISS
K301‑ac SKISSTIkSTPSGKR
K310 TPSGKRYKFVATGHG
T314 KRYKFVATGHGKyEK
K318 FVATGHGKyEKVLVD
Y319‑p VATGHGKyEKVLVDE
  LSP1 iso3  
- gap
T23 LEKLLRLTTQWREED
R27 LRLTTQWREEDEEEA
K52 RQLQDQDKDKEDDGG
S61 KEDDGGHSLEQPGQQ
G66 GHSLEQPGQQTLISL
S72 PGQQTLISLKSSELD
K74 QQTLISLKSSELDED
S75 QTLISLKSSELDEDE
S88 DEGFGDWSQKPEPRQ
F97 KPEPRQQFWGNEGTA
T107 NEGTAEGTEPSQSER
S110 TAEGTEPSQSERPEE
R114 TEPSQSERPEEKQTE
- gap
Q126 QTEESSHQAKVHLEE
S134 AKVHLEESNLSYREP
S137 HLEESNLSYREPDPE
S150‑p PEDAVGGsGEAEEVR
T158‑p GEAEEVRtPsPLALE
S160‑p AEEVRtPsPLALEDt
T167‑p sPLALEDtVELssPP
S171‑p LEDtVELssPPLsPT
S172‑p EDtVELssPPLsPTT
S176‑p ELssPPLsPTTKLAD
T178 ssPPLsPTTKLADRT
T179 sPPLsPTTKLADRTE
T185 TTKLADRTESLNRSI
S187 KLADRTESLNRSIKK
S191 RTESLNRSIKKSNSV
S201 KSNSVKKSQPTLPIS
T209 QPTLPISTIDERLQQ
Y217 IDERLQQYTQATESS
T218 DERLQQYTQATESSG
T227 ATESSGRTPKLSRQP
S231 SGRTPKLSRQPSIEL
S235 PKLSRQPSIELPSMA
S240 QPSIELPSMAVASTK
S245 LPSMAVASTKTLWET
T248 MAVASTKTLWETGEV
T252 STKTLWETGEVQSQS
S265 QSASKTPSCQDIVAG
K283 KKSLWEQKGGSKISS
K293 SKISSTIKSTPSGKR
K302 TPSGKRYKFVATGHG
T306 KRYKFVATGHGKYEK
K310 FVATGHGKYEKVLVD
Y311 VATGHGKYEKVLVDE
  rat

 
S6 __MAEAASDPRCQEQ
T25 AEDDKGLTTQWREED
R29 KGLTTQWREEDEEEA
K54‑ac RQLQDQDkDEEDEGG
F63 EEDEGGHFLEQPGQQ
G68 GHFLEQPGQQALVSL
S74 PGQQALVSLKSSELD
K76 QQALVSLKSSELDED
S77 QALVSLKSSELDEDE
S90 DEGFGDWSQKQEPPR
S100‑p QEPPRQQsWENEGTA
S110‑p NEGTAEGsEPsPSES
S113‑p TAEGsEPsPSESAEE
S117 sEPsPSESAEEKQTE
- gap
Q129 QTEDSSHQAKVHLEE
S137 AKVHLEESNLSHSDP
S140 HLEESNLSHSDPNIE
S153 IEDDVGGSGETEEHL
T167‑p LISHQARtPsPLALE
S169‑p SHQARtPsPLALEDT
T176 sPLALEDTAELSsPP
S180 LEDTAELSsPPLsPT
S181‑p EDTAELSsPPLsPTV
S185‑p ELSsPPLsPTVKLAD
T187 SsPPLsPTVKLADRT
V188 sPPLsPTVKLADRTE
T194 TVKLADRTEsLNRSI
S196‑p KLADRTEsLNRSIQK
S200 RTEsLNRSIQKSNSV
S210‑p KSNSVKKsQPTLPIS
T218 QPTLPISTIDERLQQ
Y226 IDERLQQYTQATESA
T227 DERLQQYTQATESAG
T236 ATESAGRTPKLSRQP
S240 AGRTPKLSRQPsIEL
S244‑p PKLSRQPsIELPSMA
S249 QPsIELPSMAVASTK
S254 LPSMAVASTKTLWET
T257 MAVASTKTLWETGEV
T261 STKTLWETGEVQTQS
S274 QSASKTPSCQDIVAG
K292‑ac KKSLWEQkGGSKISS
K302‑ac SKISSTIkSTPSGKR
K311‑ac TPSGKRYkFVATGHG
T315 KRYkFVATGHGkyEK
K319‑ac FVATGHGkyEKVLVD
Y320‑p VATGHGkyEKVLVDE
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