a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein
Biological Process: phosphoinositide-mediated signaling; platelet activation; positive regulation of apoptosis; regulation of cell size; regulation of GTPase activity; regulation of phosphoinositide 3-kinase cascade; regulation of small GTPase mediated signal transduction; T cell costimulation; vascular endothelial growth factor receptor signaling pathway