a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed exclusively in hematopoietic cells. Important in hematopoiesis, playing a role in T-cell and B-cell development and activation. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; GEFs, Rac/Rho; GEFs; Motility/polarity/chemotaxis
Molecular Function: guanyl-nucleotide exchange factor activity; metal ion binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; transcription factor activity
Biological Process: G-protein coupled receptor protein signaling pathway; immune response; integrin-mediated signaling pathway; neutrophil chemotaxis; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; platelet activation; positive regulation of apoptosis; positive regulation of GTPase activity; positive regulation of natural killer cell mediated cytotoxicity; regulation of cell size; regulation of GTPase activity; regulation of phosphoinositide 3-kinase cascade; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; T cell costimulation; T cell differentiation; vascular endothelial growth factor receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.