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Protein Page:
FETUA

Overview
FETUA Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond. Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. Belongs to the fetuin family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3q27.3
Cellular Component: endoplasmic reticulum lumen; extracellular matrix; extracellular region; extracellular space; Golgi apparatus
Molecular Function: endopeptidase inhibitor activity
Biological Process: acute-phase response; cellular protein metabolic process; negative regulation of bone mineralization; neutrophil degranulation; platelet degranulation; positive regulation of phagocytosis; post-translational protein modification; regulation of inflammatory response
Reference #:  P02765 (UniProtKB)
Alt. Names/Synonyms: A2HS; AHS; AHSG; Alpha-2-HS-glycoprotein; Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B; Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; FETUA; Fetuin-A; HSGA
Gene Symbols: AHSG
Molecular weight: 39,325 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FETUA

Protein Structure Not Found.

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