Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions. Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are held together by a single disulfide bond. Synthesized in liver and selectively concentrated in bone matrix. Secreted in plasma. It is also found in dentin in much higher quantities than other plasma proteins. Belongs to the fetuin family. Note: This description may include information from UniProtKB.
Biological Process: acute-phase response; cellular protein metabolic process; negative regulation of bone mineralization; neutrophil degranulation; platelet degranulation; positive regulation of phagocytosis; post-translational protein modification; regulation of inflammatory response