an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Molecular Function: chaperone binding; enzyme binding; identical protein binding; microtubule binding; protein binding; Ran GTPase binding; ubiquitin-protein ligase activity
Biological Process: negative regulation of apoptosis; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; protein amino acid phosphorylation; protein complex localization; protein sumoylation; regulation of apoptosis; regulation of signal transduction; sister chromatid cohesion
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.