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Protein Page:
Survivin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Survivin an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: centriole; chromosome, pericentric region; cytoplasm; cytoplasmic microtubule; cytosol; interphase microtubule organizing center; microtubule; midbody; nuclear chromosome; nucleoplasm; nucleus; spindle; spindle microtubule
Molecular Function: caspase inhibitor activity; chaperone binding; cobalt ion binding; cofactor binding; cysteine protease inhibitor activity; enzyme binding; identical protein binding; metal ion binding; microtubule binding; protein binding; protein heterodimerization activity; protein homodimerization activity; Ran GTPase binding; tubulin binding; ubiquitin-protein ligase activity; zinc ion binding
Biological Process: cell division; cellular protein metabolic process; chromosome segregation; cytokinesis; establishment of chromosome localization; G2/M transition of mitotic cell cycle; mitosis; mitotic cell cycle; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of exit from mitosis; positive regulation of mitotic cell cycle; post-translational protein modification; protein amino acid phosphorylation; protein complex localization; protein sumoylation; protein ubiquitination; regulation of signal transduction; small GTPase mediated signal transduction; spindle checkpoint; transcription, DNA-dependent
Reference #:  O15392 (UniProtKB)
Alt. Names/Synonyms: API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5; Baculoviral IAP repeat-containing protein 5; BIRC5; EPR-1; IAP4; survivin variant 3 alpha
Gene Symbols: BIRC5
Molecular weight: 16,389 Da
Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Survivin

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: T48‑p
apoptosis, induced: S20‑p
apoptosis, inhibited: T34‑p
cell cycle regulation: S20‑p, T48‑p, T117‑p
cell growth, altered: T34‑p
cytoskeletal reorganization: T34‑p
transcription, induced: T34‑p
transcription, inhibited: T34‑p
activity, induced: T34‑p
intracellular localization: S20‑p, T34‑p, T48‑p, T117‑p, K129‑ac
molecular association, regulation: S20‑p, T34‑p, T48‑p, T117‑p, K129‑ac
phosphorylation: S20‑p
protein stabilization: S20‑p, T34‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
4 0 S20‑p FLKDHRIstFkNWPF
2 0 T21‑p LKDHRIstFkNWPFL
1 0 K23‑ac DHRIstFkNWPFLEG
0 2 K23 DHRIstFKNWPFLEG
13 11 T34‑p FLEGCACtPERMAEA
1 0 T48‑p AGFIHCPtENEPDLA
0 1 K78‑ub DDPIEEHkKHSSGCA
1 1 K90‑ac GCAFLSVkkQFEELT
1 0 K90‑ub GCAFLSVkkQFEELT
1 0 K91‑ub CAFLSVkkQFEELTL
1 2 K110‑ac KLDRERAkNkIAkEt
1 1 K112‑ac DRERAkNkIAkEtNN
1 1 K115‑ac RAkNkIAkEtNNkkk
2 0 T117‑p kNkIAkEtNNkkkEF
1 1 K120‑ac IAkEtNNkkkEFEET
1 1 K121‑ac AkEtNNkkkEFEETA
1 1 K122‑ac kEtNNkkkEFEETAk
1 1 K129‑ac kEFEETAkkVRRAIE
1 1 K130‑ac EFEETAkkVRRAIEQ
8888 : Phospho-Survivin (Thr34) (D2E11) Rabbit mAb
  Survivin iso2  
S20 FLKDHRISTFKNWPF
T21 LKDHRISTFKNWPFL
K23 DHRISTFKNWPFLEG
K23 DHRISTFKNWPFLEG
T34 FLEGCACTPERMAEA
T48 AGFIHCPTENEPDLA
K101 RITREEHKKHSSGCA
K113 GCAFLSVKKQFEELT
K113 GCAFLSVKKQFEELT
K114 CAFLSVKKQFEELTL
K133 KLDRERAKNKIAKET
K135 DRERAKNKIAKETNN
K138 RAKNKIAKETNNKKK
T140 KNKIAKETNNKKKEF
K143 IAKETNNKKKEFEET
K144 AKETNNKKKEFEETA
K145 KETNNKKKEFEETAK
K152 KEFEETAKKVRRAIE
K153 EFEETAKKVRRAIEQ
8888 : Phospho-Survivin (Thr34) (D2E11) Rabbit mAb
  mouse

► Hide Isoforms
 
A20 YLKNYRIATFkNWPF
T21 LKNYRIATFkNWPFL
K23 NYRIATFKNWPFLED
K23‑ub NYRIATFkNWPFLED
T34‑p FLEDCACtPERMAEA
T48 AGFIHCPTENEPDLA
R78 DNPIEEHRKHSPGCA
K90 GCAFLTVKKQMEELT
K90 GCAFLTVKKQMEELT
K91 CAFLTVKKQMEELTV
K110 KLDRQRAKNKIAKET
K112 DRQRAKNKIAKETNN
K115 RAKNKIAKETNNKQK
T117 KNKIAKETNNKQKEF
K120 IAKETNNKQKEFEET
Q121 AKETNNKQKEFEETA
K122 KETNNKQKEFEETAK
K129 KEFEETAKTTRQSIE
T130 EFEETAKTTRQSIEQ
  Survivin iso2  
A20 YLKNYRIATFKNWPF
T21 LKNYRIATFKNWPFL
K23 NYRIATFKNWPFLED
K23 NYRIATFKNWPFLED
T34 FLEDCACTPERMAEA
T48 AGFIHCPTENEPDLA
R78 DNPIEEHRKHSPGCA
K90 GCAFLTVKKQMEELT
K90 GCAFLTVKKQMEELT
K91 CAFLTVKKQMEELTV
K110‑ac KLDRQRAkNKIVCMI
K112 DRQRAkNKIVCMIEN
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
Y20 YLKDHRIYTFKNWPF
T21 LKDHRIYTFKNWPFL
K23 DHRIYTFKNWPFLED
K23 DHRIYTFKNWPFLED
T34 FLEDCSCTPERMAEA
T48 AGFIHCPTENEPDLA
R78 DNPIEEHRKHSPGCA
K90 GCAFLTVKKQVEELT
K90 GCAFLTVKKQVEELT
K91 CAFLTVKKQVEELTV
K110 KLDKQRAKNKIAKET
K112 DKQRAKNKIAKETNN
K115 RAKNKIAKETNNKQK
T117 KNKIAKETNNKQKEF
K120 IAKETNNKQKEFEET
Q121 AKETNNKQKEFEETR
K122 KETNNKQKEFEETRR
R129 KEFEETRRTVRQSIE
T130 EFEETRRTVRQSIEQ
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