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Protein Page:
STF-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STF-1 a nuclear hormone receptor of the NR5 subfamily. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor
Chromosomal Location of Human Ortholog: 9q33
Cellular Component: nucleoplasm; nucleus
Molecular Function: chromatin binding; DNA binding; enzyme binding; ligand-dependent nuclear receptor activity; phospholipid binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; transcription coactivator activity
Biological Process: cell-cell signaling; hormone-mediated signaling; positive regulation of transcription from RNA polymerase II promoter; primary sex determination; regulation of steroid biosynthetic process; tissue development; transcription initiation from RNA polymerase II promoter
Disease: 46,xy Sex Reversal 3; Premature Ovarian Failure 7; Spermatogenic Failure 8
Reference #:  Q13285 (UniProtKB)
Alt. Names/Synonyms: AD4BP; adrenal 4 binding protein; Adrenal 4-binding protein; ELP; FTZ1; FTZF1; Fushi tarazu factor homolog 1; NR5A1; nuclear receptor AdBP4; Nuclear receptor subfamily 5 group A member 1; nuclear receptor subfamily 5, group A, member 1; POF7; SF-1; SF1; Steroid hormone receptor Ad4BP; Steroidogenic factor 1; steroidogenic factor-1; STF-1; STF1
Gene Symbols: NR5A1
Molecular weight: 51,636 Da
Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STF-1

Protein Structure Not Found.
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Sites Implicated In
transcription, induced: K119‑ub, S203‑p
transcription, inhibited: K119‑sm
activity, induced: S203‑p
molecular association, regulation: K119‑sm, K119‑ub

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K34‑ac LLTCESCkGFFkRTV
1 1 K38‑ac ESCkGFFkRTVQNNK
1 0 K72‑ac CPFCRFQkCLTVGMR
0 1 K100‑m2 NKFGPMYkRDRALKQ
1 0 K119‑ub QIRANGFkLETGPPM
7 0 K119‑sm QIRANGFkLETGPPM
9 0 K194‑sm AFPGRAIkSEYPEPY
10 0 S203‑p EYPEPYAsPPQPGLP
1 0 S430‑p LVEVRALsMQAKEYL
  mouse

 
K34 LLTCESCKGFFKRTV
K38 ESCKGFFKRTVQNNK
K72 CPFCRFQKCLTVGMR
K100 NKFGPMYKRDRALKQ
K119 QIRANGFKLETGPPM
K119‑sm QIRANGFkLETGPPM
K194‑sm AFSNRTIkSEYPEPY
S203‑p EYPEPYAsPPQQPGP
S431 LVEVRALSMQAKEYL
  rat

 
K34 LLTCESCKGFFKRTV
K38 ESCKGFFKRTVQNNK
K72 CPFCRFQKCLTVGMR
K100 NKFGPMYKRDRALKQ
K119 QIRANGFKLETGPPM
K119 QIRANGFKLETGPPM
K194 AFSNRTIKSEYPEPY
S203 EYPEPYASPPQQPGP
S431 LVEVRALSMQAKEYL
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