transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Binds to the IFN-stimulated response element (ISRE) and to the Gas element. This multiprotein transcription factor is termed ISGF3. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Molecular Function: identical protein binding; protein binding
Biological Process: defense response to virus; JAK-STAT cascade; positive regulation of defense response to virus by host; regulation of protein amino acid phosphorylation; regulation of transcription from RNA polymerase II promoter
Alt. Names/Synonyms: interferon alpha induced transcriptional activator; ISGF-3; MGC59816; p113; Signal transducer and activator of transcription 2; signal transducer and activator of transcription 2, 113kDa; STAT113; STAT2