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Protein Page:
STAT1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
STAT1 transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 2q32.2
Cellular Component: axon; cytoplasm; cytosol; dendrite; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function: double-stranded DNA binding; enzyme binding; identical protein binding; protein binding; protein homodimerization activity; signal transducer activity; transcription factor activity; tumor necrosis factor receptor binding
Biological Process: apoptosis; blood circulation; defense response to virus; endothelial cell migration; JAK-STAT cascade; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of viral protein levels in host cell; positive regulation of mesenchymal cell proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of transcription from RNA polymerase II promoter; response to cAMP; response to cytokine stimulus; response to peptide hormone stimulus; transcription, DNA-dependent; tumor necrosis factor-mediated signaling pathway; viral reproduction
Disease: Immunodeficiency 31a; Immunodeficiency 31b; Immunodeficiency 31c
Reference #:  P42224 (UniProtKB)
Alt. Names/Synonyms: DKFZp686B04100; ISGF-3; signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT1; STAT91; Transcription factor ISGF-3 components p91/p84
Gene Symbols: STAT1
Molecular weight: 87,335 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STAT1

Protein Structure Not Found.
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Sites Implicated In
apoptosis, induced: S727‑p
apoptosis, inhibited: S727‑p
cell cycle regulation: Y701‑p
cell differentiation, altered: Y701‑p
cell growth, altered: Y701‑p, S727‑p
transcription, altered: Y701‑p, S727‑p
transcription, induced: Y701‑p, S727‑p
transcription, inhibited: Y701‑p
activity, induced: Y701‑p, S727‑p
intracellular localization: Y701‑p
molecular association, regulation: Y701‑p, S727‑p
phosphorylation: K703‑sm
protein degradation: Y701‑p
sumoylation: Y701‑p, S727‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
2 0 R31‑m1 DSFPMEIrQYLAQWL
1 0 R31‑m2 DSFPMEIrQYLAQWL
0 1 K40‑ub YLAQWLEkQDWEHAA
0 12 Y68‑p LSQLDDQySRFSLEN
0 19 Y106‑p IQMSMIIySCLKEER
0 2 K138‑ub QSTVMLDkQKELDSK
0 1 S162‑p CIEHEIKsLEDLQDE
0 3 Y170‑p LEDLQDEyDFkCKTL
0 1 K173‑ac LQDEyDFkCKTLQNR
0 2 K173‑ub LQDEyDFkCKTLQNR
0 1 T184‑p LQNREHEtNGVAKSD
0 6 K193‑ub GVAKSDQkQEQLLLK
0 1 K209‑ub MYLMLDNkRKEVVHK
0 1 K216 kRKEVVHKIIELLNV
0 1 V223 KIIELLNVTELTQNA
0 1 T227 LLNVTELTQNALIND
0 3 K240‑ub NDELVEWkRRQQSAC
0 7 K296‑ub YEHDPITkNkQVLWD
0 1 K298‑ub HDPITkNkQVLWDRT
0 2 K375‑ub VNERNTVkGFRKFNI
0 1 K379 NTVkGFRKFNILGTH
0 1 K379 NTVkGFRKFNILGTH
3 2 K410‑ac EFRHLQLkEQkNAGt
0 11 K410‑ub EFRHLQLkEQkNAGt
3 1 K413‑ac HLQLkEQkNAGtRTN
0 1 T417‑p kEQkNAGtRTNEGPL
0 5 K511‑ub WQFSSVTkRGLNVDQ
0 2 K525‑ub QLNMLGEkLLGPNAs
0 7 S532‑p kLLGPNAsPDGLIPW
0 2 K544‑ub IPWTRFCkENINDKN
0 1 S583‑p GCIMGFIsKERERAL
0 13 K592‑ub ERERALLkDQQPGTF
0 1 K636‑ub HAVEPYTkKELsAVT
0 1 K637 AVEPYTkKELsAVTF
0 1 S640‑p PYTkKELsAVTFPDI
0 15 K652‑ub PDIIRNYkVMAAENI
0 2 K665‑ub NIPENPLkYLyPNID
0 4 Y668‑p ENPLkYLyPNIDKDH
0 1 K673 YLyPNIDKDHAFGKY
0 1 K679 DKDHAFGKYYSRPKE
0 5 T699‑p ELDGPKGtGyIktEL
131 54 Y701‑p DGPKGtGyIktELIs
6 1 K703‑sm PKGtGyIktELIsVS
0 3 T704‑p KGtGyIktELIsVSE
2 0 S708‑p yIktELIsVSEVHPS
0 2 T719 VHPSRLQTTDNLLPM
0 1 T720 HPSRLQTTDNLLPMs
80 101 S727‑p TDNLLPMsPEEFDEV
0 1 S735 PEEFDEVSRIVGsVE
0 1 S740‑p EVSRIVGsVEFDSMM
1 0 S745 VGsVEFDSMMNTV__
1 0 N748 VEFDSMMNTV_____
5167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Sepharose Bead Conjugate)
5375 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Biotinylated)
7649 : Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb
8009 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
8062 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (PE Conjugate)
8183 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
9167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb
9171 : Phospho-Stat1 (Tyr701) Antibody
9174 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
8826 : Phospho-Stat1 (Ser727) (D3B7) Rabbit mAb
9177 : Phospho-Stat1 (Ser727) Antibody
  STAT1 iso2  
R31 DSFPMEIRQYLAQWL
R31 DSFPMEIRQYLAQWL
K40 YLAQWLEKQDWEHAA
Y68 LSQLDDQYSRFSLEN
Y106 IQMSMIIYSCLKEER
K138 QSTVMLDKQKELDSK
S162 CIEHEIKSLEDLQDE
Y170 LEDLQDEYDFKCKTL
K173 LQDEYDFKCKTLQNR
K173 LQDEYDFKCKTLQNR
T184 LQNREHETNGVAKSD
K193 GVAKSDQKQEQLLLK
K209 MYLMLDNKRKEVVHK
K216 KRKEVVHKIIELLNV
V223 KIIELLNVTELTQNA
T227 LLNVTELTQNALIND
K240 NDELVEWKRRQQSAC
K296 YEHDPITKNKQVLWD
K298 HDPITKNKQVLWDRT
K375 VNERNTVKGFRKFNI
K379 NTVKGFRKFNILGTH
K379 NTVKGFRKFNILGTH
K410 EFRHLQLKEQKNAGT
K410 EFRHLQLKEQKNAGT
K413 HLQLKEQKNAGTRTN
T417 KEQKNAGTRTNEGPL
K511 WQFSSVTKRGLNVDQ
K525 QLNMLGEKLLGPNAS
S532 KLLGPNASPDGLIPW
K544 IPWTRFCKENINDKN
S583 GCIMGFISKERERAL
K592 ERERALLKDQQPGTF
K636 HAVEPYTKKELSAVT
K637 AVEPYTKKELSAVTF
S640 PYTKKELSAVTFPDI
K652 PDIIRNYKVMAAENI
K665 NIPENPLKYLYPNID
Y668 ENPLKYLYPNIDKDH
K673 YLYPNIDKDHAFGKY
K679 DKDHAFGKYYSRPKE
T699 ELDGPKGTGYIKTEL
Y701 DGPKGTGYIKTELIS
K703 PKGTGYIKTELISVS
T704 KGTGYIKTELISVSE
S708 YIKTELISVSEV___
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
R31 DSFPMEIRQYLAQWL
R31 DSFPMEIRQYLAQWL
K40 YLAQWLEKQDWEHAA
Y68 LSQLDDQYSRFSLEN
Y106 VQMSMIIYNCLKEER
K138‑ub QNTVMLDkQKELDSK
T162 CIEQEIKTLEELQDE
Y170 LEELQDEYDFKCKTS
K173 LQDEYDFKCKTSQNR
K173 LQDEYDFKCKTSQNR
A184 SQNREGEANGVAKSD
K193‑ub GVAKSDQkQEQLLLH
K209 MFLMLDNKRKEIIHK
K216 KRKEIIHKIRELLNS
S223 KIRELLNSIELTQNT
T227 LLNSIELTQNTLIND
K240 NDELVEWKRRQQSAC
K296‑ub YEPDPITkNKQVLSD
K298 PDPITkNKQVLSDRT
K375 VNEKNTVKGFRkFNI
K379 NTVKGFRKFNILGTH
K379‑ub NTVKGFRkFNILGTH
K410 ELRHLQLKEQKNAGN
K410 ELRHLQLKEQKNAGN
K413 HLQLKEQKNAGNRTN
N417 KEQKNAGNRTNEGPL
K511 WQFSSVTKRGLNADQ
K525‑ub QLSMLGEkLLGPNAG
G532 kLLGPNAGPDGLIPW
K544‑ub IPWTRFCkENINDKN
S583 GCIMGFISKERERAL
K592‑ub ERERALLkDQQPGTF
K636 HAVEPYTKkELSAVT
K637‑ub AVEPYTKkELSAVTF
S640 PYTKkELSAVTFPDI
K652‑ub PDIIRNYkVMAAENI
K665‑ub NIPENPLkYLYPNID
Y668 ENPLkYLYPNIDkDH
K673‑ub YLYPNIDkDHAFGkY
K679‑ub DkDHAFGkYYSRPKE
T699 ELDDPKRTGyIKTEL
Y701‑p DDPKRTGyIKTELIs
K703 PKRTGyIKTELIsVS
T704 KRTGyIKTELIsVSE
S708‑p yIKTELIsVSEVHPS
T719‑p VHPSRLQttDNLLPM
T720‑p HPSRLQttDNLLPMs
S727‑p tDNLLPMsPEEFDEM
S735‑p PEEFDEMsRIVGPEF
P740 EMsRIVGPEFDsMMs
S744‑p IVGPEFDsMMsTV__
S747‑p PEFDsMMsTV_____
5167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Sepharose Bead Conjugate)
5375 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Biotinylated)
7649 : Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb
8009 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
8062 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (PE Conjugate)
8183 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
9167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb
9171 : Phospho-Stat1 (Tyr701) Antibody
9174 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
8826 : Phospho-Stat1 (Ser727) (D3B7) Rabbit mAb
9177 : Phospho-Stat1 (Ser727) Antibody
  rat

 
R31 DSFPMEIRQYLAQWL
R31 DSFPMEIRQYLAQWL
K40 YLAQWLEKQDWEHAA
Y68 LSQLDDQYSRFSLEN
H106 VQMSMIIHNCLKEER
K138 QNTVMLDKQKELDSK
T162 CIEHEIKTLEDLQDE
Y170 LEDLQDEYDFKCKTS
K173 LQDEYDFKCKTSQNR
K173 LQDEYDFKCKTSQNR
A184 SQNRESEANGVAKSD
K193 GVAKSDQKQEQLLLH
K209 MFLMLDNKRKEIIHk
K216‑ac KRKEIIHkIRELLNs
S223‑p kIRELLNsIELtQNT
T227‑p LLNsIELtQNTLIND
K240 NDELVEWKRRQQSAC
K296 YEQDPITKNKQVLSD
K298 QDPITKNKQVLSDRT
K375 VNEKNTVKGFRkFNI
K379‑ac NTVKGFRkFNILGTH
K379 NTVKGFRKFNILGTH
K410‑ac EFRHLQLkEQKNAGN
K410 EFRHLQLKEQKNAGN
K413 HLQLkEQKNAGNRTN
N417 kEQKNAGNRTNEGPL
K511 WQFSSVTKRGLNADQ
K525 QLSMLGEKLLGPNAG
G532 KLLGPNAGPDGLIPW
K544 IPWTRFCKENINDKN
S583 GCIMGFISKERERAL
K592 ERERALLKDQQPGTF
K636 HAVEPYTKKELSAVT
K637 AVEPYTKKELSAVTF
S640 PYTKKELSAVTFPDI
K652 PDIIRNYKVMAAENI
K665 NIPENPLKYLYPNID
Y668 ENPLKYLYPNIDKDH
K673 YLYPNIDKDHAFGKY
K679 DKDHAFGKYYSRPKE
T699 ELDDPKRTGyIKTEL
Y701‑p DDPKRTGyIKTELIS
K703 PKRTGyIKTELISVS
T704 KRTGyIKTELISVSE
S708 yIKTELISVSEVHPS
S719‑p VHPSRLQsTENLLPM
T720 HPSRLQsTENLLPMs
S727‑p TENLLPMsPEEFDEM
S735 PEEFDEMSKIVGSEF
S740 EMSKIVGSEFDSMMS
S744 IVGSEFDSMMSAV__
S747 SEFDSMMSAV_____
5167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Sepharose Bead Conjugate)
5375 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Biotinylated)
7649 : Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb
8009 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
8062 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (PE Conjugate)
8183 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (Alexa Fluor(R) 555 Conjugate)
9167 : Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb
9171 : Phospho-Stat1 (Tyr701) Antibody
8826 : Phospho-Stat1 (Ser727) (D3B7) Rabbit mAb
9177 : Phospho-Stat1 (Ser727) Antibody
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