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Protein Page:
SMAD5 (human)

Overview
SMAD5 transcription factor phosphorylated and activated by bone morphogenetic protein receptor kinases. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where they regulate transcription of target genes. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; protein complex
Molecular Function: protein binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; ubiquitin protein ligase binding
Biological Process: BMP signaling pathway; embryonic pattern specification
Reference #:  Q99717 (UniProtKB)
Alt. Names/Synonyms: DKFZp781C1895; DKFZp781O1323; Dwfc; hSmad5; JV5-1; MAD homolog 5; MAD, mothers against decapentaplegic homolog 5; MADH5; Mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5; Mothers against DPP homolog 5; SMA- and MAD-related protein 5; SMAD 5; SMAD family member 5; SMAD, mothers against DPP homolog 5; SMAD5
Gene Symbols: SMAD5
Molecular weight: 52,258 Da
Basal Isoelectric point: 7.63  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SMAD5

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S12‑p ASLFSFTsPAVKRLL
0 1 S57‑p EELEKALssPGQPsK
0 4 S58‑p ELEKALssPGQPsKC
0 4 S63‑p LssPGQPsKCVTIPR
0 9 S133‑p YHYKRVEsPVLPPVL
0 1 S152‑p NEFNPQHsLLVQFRN
0 1 S188‑p NNTPFPLsPNSPYPP
0 1 T243 DNSQPMDTSNNMIPQ
0 1 T322 SNVNRNSTIENTRRH
0 10 S462‑p GSPLNPIssVs____
6 52 S463‑p SPLNPIssVs_____
6 58 S465‑p LNPIssVs_______
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
  mouse

 
S12 ASLFSFTSPAVKRLL
S57 EELEKALSSPGQPSK
S58 ELEKALSSPGQPSKC
S63 LSSPGQPSKCVTIPR
S133‑p YHYKRVEsPVLPPVL
S152 NEFNPQHSLLVQFRN
S188 NNAPFPLSPNSPYPP
T243‑p DNSQPMDtSSNMIPQ
T322‑p SNVNRNStIENTRRH
S462 GSPLNPISsVs____
S463‑p SPLNPISsVs_____
S465‑p LNPISsVs_______
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
  rat

 
S12 ASLFSFTSPAVKRLL
S57 EELEKALSSPGQPSK
S58 ELEKALSSPGQPSKC
S63 LSSPGQPSKCVTIPR
S133 YHYKRVESPVLPPVL
S152 NEFNPQHSLLVQFRN
S188 NSTPFPLSPNSPYPP
T243 DNSQPMDTSNNMIPQ
T322 SNVNRNSTIENTRRH
S462 GSPLNPISSVs____
S463 SPLNPISSVs_____
S465‑p LNPISSVs_______
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
9511 : Phospho-Smad1 (Ser463/465)/ Smad5 (Ser463/465)/ Smad8 (Ser426/428) Antibody
9516 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb
9576 : Phospho-Smad1/5 (Ser463/465) (41D10) Rabbit mAb (Biotinylated)
11971 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (ChIP formulated)
12428 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb (PE Conjugate)
13820 : Phospho-Smad1/5 (Ser463/465) (D5B10) Rabbit mAb
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