transcription factor phosphorylated and activated by bone morphogenetic protein type 1 receptor kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated forms dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is stimulated. Note: This description may include information from UniProtKB.
Cellular Component: cytoplasm; cytosol; integral to membrane; intracellular; nuclear inner membrane; nucleoplasm; nucleus; protein complex; transcription factor complex
Molecular Function: identical protein binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; receptor signaling protein activity; transcription factor activity; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Biological Process: BMP signaling pathway; cardiac muscle cell proliferation; cartilage development; embryonic pattern specification; gamete generation; hindbrain development; homeostatic process; inflammatory response; MAPKKK cascade; mesodermal cell fate commitment; midbrain development; negative regulation of cell proliferation; osteoblast fate commitment; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; primary microRNA processing; signal transduction; SMAD protein complex assembly; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; ureteric bud development
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.