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Protein Page:
CASP12 (mouse)

Overview
CASP12 Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. Belongs to the peptidase C14A family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.22.-; Protease
Cellular Component: cytosol; endoplasmic reticulum; intracellular membrane-bound organelle; nucleus
Molecular Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; peptidase activity; protease binding; protein binding
Biological Process: apoptosis; positive regulation of apoptosis; positive regulation of caspase activity; protein autoprocessing; proteolysis; unfolded protein response
Reference #:  O08736 (UniProtKB)
Alt. Names/Synonyms: CASP-12; Casp12; caspase 12; Caspase-12; CASPC
Gene Symbols: Casp12
Molecular weight: 47,854 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CASP12

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S85 ANSQEQLSLQFSNDE
0 1 N90 QLSLQFSNDEDDGPQ
0 2 S104‑p QKICTPSsPSESKRK
0 1 T220 VVLKENLTAQEMETE
0 1 S332‑p LSCKWNNsITKAHVE
0 1 S408‑p MPTIERVsMTRyFyL
0 1 Y412‑p ERVsMTRyFyLFPGN
0 1 Y414‑p VsMTRyFyLFPGN__
  human

 
S85 WNSKKQLSSDISSDG
S90 QLSSDISSDGEREAN
- gap
T142‑p VVIKENLtAQEMETA
A254 QGNICNDAVTKAHVE
S330 LPTIERLSMTRYFYL
Y334 ERLSMTRYFYLFPGN
Y336 LSMTRYFYLFPGN__
  rat

 
S85‑p ANSDKQLsLQFPsDD
S90‑p QLsLQFPsDDEEDEL
S105 QKMFTPSSASESRGK
T221 VVIKENLTAQEMETE
S333 LSHRWNNSITKAHVE
S409 MPTIERVSMTRYFYL
Y413 ERVSMTRYFYLFPGN
Y415 VSMTRYFYLFPGN__
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