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Protein Page:
RHOA (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RHOA a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; Motility/polarity/chemotaxis; Oncoprotein; G protein, monomeric, Rho; G protein
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: apical junction complex; cell cortex; cell junction; cleavage furrow; cytoskeleton; cytosol; endoplasmic reticulum membrane; endosome; focal adhesion; lamellipodium; midbody; plasma membrane; vesicle
Molecular Function: GTP binding; GTPase activity; myosin binding; protein binding
Biological Process: actin cytoskeleton organization and biogenesis; apical junction assembly; axon guidance; blood coagulation; endothelial cell migration; ephrin receptor signaling pathway; negative chemotaxis; negative regulation of axonogenesis; nerve growth factor receptor signaling pathway; phosphoinositide-mediated signaling; platelet activation; positive regulation of axonogenesis; positive regulation of cytokinesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of lipase activity; positive regulation of neuron differentiation; positive regulation of NF-kappaB import into nucleus; positive regulation of stress fiber formation; regulation of actin cytoskeleton organization and biogenesis; regulation of axonogenesis; regulation of cell migration; regulation of osteoblast proliferation; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; small GTPase mediated signal transduction; substantia nigra development; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; viral reproduction
Reference #:  P61586 (UniProtKB)
Alt. Names/Synonyms: Aplysia ras-related homolog 12; ARH12; ARHA; h12; oncogene RHO H12; ras homolog gene family, member A; Rho cDNA clone 12; RHO12; RHOA; RHOH12; small GTP binding protein RhoA; Transforming protein RhoA
Gene Symbols: RHOA
Molecular weight: 21,768 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RHOA

Protein Structure Not Found.


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Sites Implicated In
cell motility, induced: S188‑p
cytoskeletal reorganization: S188‑p
activity, inhibited: S188‑p
intracellular localization: S188‑p
molecular association, regulation: S188‑p
protein stabilization: S188‑p

Modification Sites and Domains  
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Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 T19‑p GDGACGKtCLLIVFs
1 2 S26‑p tCLLIVFsKDQFPEV
1 14 Y34‑p KDQFPEVyVPTVFEN
1 0 Y34‑ad KDQFPEVyVPTVFEN
1 10 Y66‑p DTAGQEDyDRLRPLS
0 4 K104‑ub EKWTPEVkHFCPNVP
0 5 K118‑ub PIILVGNkkDLRNDE
0 3 K119‑ub IILVGNkkDLRNDEH
0 1 K133 HTRRELAKMkQEPVk
0 1 K133‑ub HTRRELAkMkQEPVk
0 1 K135 RRELAkMKQEPVkPE
1 101 K135‑ub RRELAkMkQEPVkPE
0 2 K140‑ub kMkQEPVkPEEGRDM
0 1 - gap
0 1 - gap
0 30 Y156‑p NRIGAFGyMECsAKT
0 1 S160‑p AFGyMECsAKTkDGV
0 1 K162 GyMECsAKTkDGVRE
0 1 K164‑ub MECsAKTkDGVREVF
10 0 S188‑p ARRGKKKsGCLVL__
  RHOA iso3  
T19 GDGACGKTCLLIVFS
S26 TCLLIVFSKDQFPEV
Y34 KDQFPEVYVPTVFEN
Y34 KDQFPEVYVPTVFEN
Y66 DTAGQEDYDRLRPLS
K104 EKWTPEVKHFCPNVP
K118 PIILVGNKKDLRNDE
K119 IILVGNKKDLRNDEH
K133 HTRRELAKMKQEPHC
K133 HTRRELAKMKQEPHC
K135 RRELAKMKQEPHCVA
K135 RRELAKMKQEPHCVA
- gap
S168‑p FKRFPCLsLLSsWGY
S172‑p PCLsLLSsWGYRRPL
- gap
- gap
- gap
- gap
- gap
  mouse

 
T19‑p GDGACGKtCLLIVFs
S26‑p tCLLIVFsKDQFPEV
Y34 KDQFPEVYVPTVFEN
Y34 KDQFPEVYVPTVFEN
Y66 DTAGQEDYDRLRPLS
K104‑ub EKWTPEVkHFCPNVP
K118‑ub PIILVGNkkDLRNDE
K119‑ub IILVGNkkDLRNDEH
K133 HTRRELAKMkQEPVK
K133 HTRRELAKMkQEPVK
K135 RRELAKMKQEPVKPE
K135‑ub RRELAKMkQEPVKPE
K140 KMkQEPVKPEEGRDM
- gap
- gap
Y156‑p NRIGAFGyMECSAkT
S160 AFGyMECSAkTKDGV
K162‑ub GyMECSAkTKDGVRE
K164 MECSAkTKDGVREVF
S188‑p ARRGKKKsGCLIL__
  rat

 
T19 GDGACGKTCLLIVFS
S26 TCLLIVFSKDQFPEV
Y34 KDQFPEVYVPTVFEN
Y34 KDQFPEVYVPTVFEN
Y66 DTAGQEDYDRLRPLS
K104 EKWTPEVKHFCPNVP
K118 PIILVGNKKDLRNDE
K119 IILVGNKKDLRNDEH
K133‑ac HTRRELAkMkQEPVK
K133 HTRRELAKMkQEPVK
K135‑ac RRELAkMkQEPVKPE
K135‑ub RRELAkMkQEPVKPE
K140 kMkQEPVKPEEGRDM
- gap
- gap
Y156‑p NRIGAFGyMECSAKT
S160 AFGyMECSAKTKDGV
K162 GyMECSAKTKDGVRE
K164 MECSAKTKDGVREVF
S188 ARRGKKKSGCLIL__
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