Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
Radixin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Radixin a cytoskeletal protein of the ERM family which includes ezrin and moiesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. May play a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: apical plasma membrane; cortical actin cytoskeleton; extracellular space; filopodium; focal adhesion; lamellipodium; microvillus; plasma membrane
Molecular Function: actin binding; ATPase binding; protein binding; protein homodimerization activity; protein kinase A binding
Biological Process: establishment of protein localization; negative regulation of cell size; negative regulation of homotypic cell-cell adhesion; positive regulation of cell migration; regulation of actin filament bundle formation; regulation of cell shape; regulation of cell size; regulation of GTPase activity; regulation of Rap protein signal transduction
Disease: Deafness, Autosomal Recessive 24
Reference #:  P35241 (UniProtKB)
Alt. Names/Synonyms: DFNB24; RADI; Radixin; RDX
Gene Symbols: RDX
Molecular weight: 68,564 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Radixin

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
intracellular localization: T564‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K3‑ub _____MPkPINVRVT
0 2 K35‑ub QLFDQVVkTVGLREV
0 10 Y55‑p QYVDSKGySTWLKLN
0 1 K60 KGySTWLKLNKKVtQ
0 4 T66‑p LKLNKKVtQQDVKkE
0 2 K72‑ub VtQQDVKkENPLQFk
0 5 K79‑ac kENPLQFkFRAkFFP
0 39 K79‑ub kENPLQFkFRAkFFP
0 1 K83 LQFkFRAKFFPEDVS
0 3 K83‑ub LQFkFRAkFFPEDVS
0 1 Y128‑p TAVLLASyAVQAKyG
0 5 Y134‑p SyAVQAKyGDyNkEI
0 1 Y137‑p VQAKyGDyNkEIHKP
0 2 K139‑ub AKyGDyNkEIHKPGY
0 1 K143 DyNkEIHKPGYLAND
0 25 K162‑ub QRVLEQHkLTKEQWE
0 1 K165 LEQHkLTKEQWEERI
0 1 K165 LEQHkLTKEQWEERI
0 5 K209‑ub GVNYFEIkNKKGTEL
0 1 K211 NYFEIkNKKGTELWL
0 8 K237‑ub HDDKLTPkIGFPWsE
0 3 S243‑p PkIGFPWsEIRNIsF
0 1 S249‑p WsEIRNIsFNDkKFV
0 28 K253‑ac RNIsFNDkKFVIKPI
0 3 K253‑ub RNIsFNDkKFVIKPI
0 1 K254 NIsFNDkKFVIKPID
0 8 K263‑ub VIKPIDKkAPDFVFy
0 218 Y270‑p kAPDFVFyAPRLRIN
0 14 Y291‑p CMGNHELyMRRRKPD
0 3 K306‑ub TIEVQQMkAQAREEK
0 1 K335‑ub KKREIAEkEKERIER
0 2 K352‑ub EELMERLkQIEEQTI
0 1 T358 LkQIEEQTIkAQKEL
0 2 K360‑ub QIEEQTIkAQKELEE
0 1 K363 EQTIkAQKELEEQtR
0 1 T369‑p QKELEEQtRKALELD
0 1 K400 RRAAEEAKSAIAKQA
0 1 K405 EAKSAIAKQAADQMK
0 1 K427‑ub ELAEFTAkIALLEEA
0 1 K435 IALLEEAKKKKEEEA
0 1 K435‑sc IALLEEAkKKKEEEA
0 1 K448 EATEWQHKAFAAQED
0 1 K458 AAQEDLEKTKEELKT
0 1 S497 DENNAEASAELSNEG
0 1 K520 ERVTETQKNERVKkQ
0 7 K526‑ub QKNERVKkQLQALSs
0 1 S532 KkQLQALSsELAQAR
0 2 S533‑p kQLQALSsELAQARD
0 1 T542‑p LAQARDEtKKtQNDV
0 1 K543 AQARDEtKKtQNDVL
0 1 K544 QARDEtKKtQNDVLH
0 2 T545‑p ARDEtKKtQNDVLHA
0 1 K556‑ac VLHAENVkAGRDKyK
0 2 K556‑ub VLHAENVkAGRDKyK
0 3 Y562‑p VkAGRDKyKtLRQIR
17 21 T564‑p AGRDKyKtLRQIRQG
3141 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody
3149 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb
3726 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (48G2) Rabbit mAb (ELISA Specific)
13756 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb (Biotinylated)
  mouse

 
K3‑ub _____MPkPINVRVT
K35‑ub QLFDQVVkTVGLREV
Y55‑p QYVDSKGySTWLkLN
K60‑ac KGySTWLkLNKKVtQ
T66‑p LkLNKKVtQQDVKkE
K72‑ub VtQQDVKkENPLQFk
K79 kENPLQFKFRAkFFP
K79‑ub kENPLQFkFRAkFFP
K83‑ac LQFkFRAkFFPEDVS
K83‑ub LQFkFRAkFFPEDVS
Y128 TAVLLASYAVQAKYG
Y134 SYAVQAKYGDYNkEI
Y137 VQAKYGDYNkEIHkP
K139‑ub AKYGDYNkEIHkPGY
K143‑ub DYNkEIHkPGYLAND
K162‑ub QRVLEQHkLTkEQWE
K165‑ac LEQHkLTkEQWEERI
K165‑ub LEQHkLTkEQWEERI
K209‑ub GVNYFEIkNkKGTEL
K211‑ub NYFEIkNkKGTELWL
K237‑ub HDDKLTPkIGFPWSE
S243 PkIGFPWSEIRNISF
S249 WSEIRNISFNDkkFV
K253‑ac RNISFNDkkFVIKPI
K253‑ub RNISFNDkkFVIKPI
K254‑ac NISFNDkkFVIKPID
K263‑ub VIKPIDKkAPDFVFy
Y270‑p kAPDFVFyAPRLRIN
Y291‑p CMGNHELyMRRRKPD
K306‑ub TIEVQQMkAQAREEK
K335 KKREIAEKEKERIER
R352 EELMERLRQIEEQtV
T358‑p LRQIEEQtVkAQkEL
K360‑ub QIEEQtVkAQkELEE
K363‑ub EQtVkAQkELEEQTR
T369 QkELEEQTRKALELE
K400‑ub RRAAEEAkSAIAkQA
K405‑ub EAkSAIAkQAADQMK
K427 ELAEFTAKIALLEEA
K435‑ub IALLEEAkKKKEEEA
K435‑sc IALLEEAkKKKEEEA
K448‑ub EATEWQHkAFAAQED
K458‑ub AAQEDLEkTKEELKT
S497‑p DENSAEAsAELSSEG
K520‑ub ERVTETQkNERVKkQ
K526‑ub QkNERVKkQLQALsS
S532‑p KkQLQALsSELAQAR
S533 kQLQALsSELAQARD
T542 LAQARDETkkTQNDV
K543‑ub AQARDETkkTQNDVL
K544‑ub QARDETkkTQNDVLH
T545 ARDETkkTQNDVLHA
K556 VLHAENVKAGRDKYK
K556‑ub VLHAENVkAGRDKYK
Y562 VkAGRDKYKtLRQIR
T564‑p AGRDKYKtLRQIRQG
3141 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody
3149 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb
3726 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (48G2) Rabbit mAb (ELISA Specific)
13756 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb (Biotinylated)
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.