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Protein Page:
PTEN (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PTEN a phosphoinositide 3-phosphatase (PIP3) and a tumor suppressor implicated in a wide variety of human cancers. Dephosphorylates inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K). A major negative regulator of the PI3K/Akt signaling pathway. Possesses a C-terminal regulatory domain that contains three phosphorylation sites which may regulate its stability. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Nuclear receptor co-regulator; Tumor suppressor; EC 3.1.3.16; EC 3.1.3.67; Carbohydrate Metabolism - inositol phosphate; Phosphatase, lipid
Chromosomal Location of Human Ortholog: 10q23.3
Cellular Component: apical plasma membrane; cell projection; cytoplasm; cytosol; internal side of plasma membrane; neuron projection; nucleoplasm; nucleus; plasma membrane
Molecular Function: enzyme binding; identical protein binding; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity; PDZ domain binding; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: apoptosis; brain morphogenesis; cell migration; cell proliferation; central nervous system development; central nervous system neuron axonogenesis; dentate gyrus development; forebrain morphogenesis; G1/S-specific negative regulation of cyclin-dependent protein kinase activity; heart development; inositol phosphate dephosphorylation; inositol phosphate metabolic process; learning and/or memory; locomotor rhythm; locomotory behavior; multicellular organismal response to stress; myelin maintenance in the central nervous system; negative regulation of axonogenesis; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell size; negative regulation of focal adhesion formation; negative regulation of organ growth; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of protein amino acid phosphorylation; negative regulation of protein kinase B signaling cascade; nerve-nerve synaptic transmission; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of transcription factor activity; prepulse inhibition; protein amino acid dephosphorylation; protein kinase B signaling cascade; protein stabilization; regulation of cellular component size; regulation of cyclin-dependent protein kinase activity; regulation of protein stability; rhythmic synaptic transmission; social behavior; synapse maturation; synaptogenesis; T cell receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
Disease: Bannayan-riley-ruvalcaba Syndrome; Cowden Syndrome 1; Endometrial Cancer; Glioma Susceptibility 2; Macrocephaly/autism Syndrome; Melanoma, Cutaneous Malignant, Susceptibility To, 1; Meningioma, Familial, Susceptibility To; Prostate Cancer; Squamous Cell Carcinoma, Head And Neck; Thyroid Carcinoma, Follicular; Vacterl Association With Hydrocephalus
Reference #:  P60484 (UniProtKB)
Alt. Names/Synonyms: 10q23del; BZS; DEC; MGC11227; MHAM; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; Mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; PTEN; PTEN1; TEP1
Gene Symbols: PTEN
Molecular weight: 47,166 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PTEN

Protein Structure Not Found.
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Sites Implicated In
autophagy, induced: S113‑p
cell cycle regulation: S380‑p, T382‑p, T383‑p
cell differentiation, altered: S380‑p, T382‑p, T383‑p
cell growth, altered: Y240‑p, Y315‑p
cell motility, altered: S229‑p, T232‑p, S380‑p, T382‑p, T383‑p
transcription, altered: S380‑p, T382‑p, T383‑p
activity, inhibited: T366‑p
enzymatic activity, induced: Y240‑p, Y315‑p
enzymatic activity, inhibited: S370‑p, S380‑p, T382‑p, T383‑p, S385‑p
intracellular localization: S113‑p, K254‑sm, T366‑p, S370‑p, S380‑p, T382‑p, T383‑p
molecular association, regulation: Y155‑p, Y336‑p, T366‑p, S370‑p, S380‑p, T382‑p, T383‑p, T401‑p
protein stabilization: Y68‑p, Y155‑p, Y336‑p, S370‑p, S380‑p, T382‑p, T383‑p, S385‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K6‑ac __MTAIIkEIVSRNk
2 0 K13‑ub kEIVSRNkRRYQEDG
1 0 Y27‑p GFDLDLTyIYPNIIA
1 45 Y46‑p AERLEGVyRNNIDDV
0 1 K66 SKHKNHYKIyNLCAE
2 1 Y68‑p HKNHYKIyNLCAERH
0 1 K80 ERHYDTAKFNCRVAQ
1 1 S113‑p EDLDQWLsEDDNHVA
2 0 K125‑ac HVAAIHCkAGkGRTG
2 0 K128‑ac AIHCkAGkGRTGVMI
2 0 Y138‑p TGVMICAyLLHRGKF
3 1 Y155‑p AQEALDFyGEVRTRD
1 1 K163‑ac GEVRTRDkkGVTIPS
0 1 K164‑ac EVRTRDkkGVTIPSQ
2 13 Y174‑p TIPSQRRyVyyysyL
0 11 Y176‑p PSQRRyVyyysyLLK
0 11 Y177‑p SQRRyVyyysyLLKN
0 11 Y178‑p QRRyVyyysyLLKNH
0 3 S179‑p RRyVyyysyLLKNHL
0 3 Y180‑p RyVyyysyLLKNHLD
0 1 S227‑p LKVKIYSsNsGPtRR
1 2 S229‑p VKIYSsNsGPtRRED
1 2 T232‑p YSsNsGPtRREDKFM
3 1 Y240‑p RREDKFMyFEFPQPL
2 0 K254‑sm LPVCGDIkVEFFHKQ
0 1 K266 HKQNKMLKKDKMFHF
2 0 K266‑sm HKQNKMLkKDKMFHF
3 0 K289‑ub GPEETSEkVENGsLC
1 0 K289‑sm GPEETSEkVENGsLC
0 6 S294‑p SEkVENGsLCDQEID
3 1 Y315‑p RADNDKEyLVLTLTK
0 1 T319 DKEyLVLTLTKNDLD
0 1 K332‑ac LDKANKDkANRyFSP
1 0 Y336‑p NKDkANRyFSPNFKV
1 0 S362‑p SNPEASSsTSVtPDV
5 2 T366‑p ASSsTSVtPDVsDNE
10 4 S370‑p TSVtPDVsDNEPDHy
1 1 Y377‑p sDNEPDHyRYsDttD
29 0 S380‑p EPDHyRYsDttDsDP
17 2 T382‑p DHyRYsDttDsDPEN
18 3 T383‑p HyRYsDttDsDPENE
10 9 S385‑p RYsDttDsDPENEPF
1 0 T398‑p PFDEDQHtQItkV__
1 0 T401‑p EDQHtQItkV_____
1 0 K402‑ac DQHtQItkV______
7960 : Non-phospho PTEN (Ser380/Thr382/Thr383) (D2D11) Rabbit mAb
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9551 : Phospho-PTEN (Ser380) Antibody
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
7960 : Non-phospho PTEN (Ser380/Thr382/Thr383) (D2D11) Rabbit mAb
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
7960 : Non-phospho PTEN (Ser380/Thr382/Thr383) (D2D11) Rabbit mAb
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
  PTEN iso2  
K179 PDMTAIIKEIVSRNK
K186 KEIVSRNKRRYQEDG
Y200 GFDLDLTYIYPNIIA
Y219 AERLEGVYRNNIDDV
K239 SKHKNHYKIYNLCAE
Y241 HKNHYKIYNLCAERH
K253 ERHYDTAKFNCRVAQ
S286 EDLDQWLSEDDNHVA
K298 HVAAIHCKAGKGRTG
K301 AIHCKAGKGRTGVMI
Y311 TGVMICAYLLHRGKF
Y328 AQEALDFYGEVRTRD
K336 GEVRTRDKKGVTIPS
K337 EVRTRDKKGVTIPSQ
Y347 TIPSQRRYVYYYSYL
Y349 PSQRRYVYYYSYLLK
Y350 SQRRYVYYYSYLLKN
Y351 QRRYVYYYSYLLKNH
S352 RRYVYYYSYLLKNHL
Y353 RYVYYYSYLLKNHLD
S400 LKVKIYSSNSGPTRR
S402 VKIYSSNSGPTRRED
T405 YSSNSGPTRREDKFM
Y413 RREDKFMYFEFPQPL
K427 LPVCGDIKVEFFHKQ
K439 HKQNKMLKKDKMFHF
K439 HKQNKMLKKDKMFHF
K462 GPEETSEKVENGSLC
K462 GPEETSEKVENGSLC
S467 SEKVENGSLCDQEID
Y488 RADNDKEYLVLTLTK
T492 DKEYLVLTLTKNDLD
K505 LDKANKDKANRYFSP
Y509 NKDKANRYFSPNFKV
S535 SNPEASSSTSVTPDV
T539 ASSSTSVTPDVSDNE
S543 TSVTPDVSDNEPDHY
Y550 SDNEPDHYRYSDTTD
S553 EPDHYRYSDTTDSDP
T555 DHYRYSDTTDSDPEN
T556 HYRYSDTTDSDPENE
S558 RYSDTTDSDPENEPF
T571 PFDEDQHTQITKV__
T574 EDQHTQITKV_____
K575 DQHTQITKV______
  mouse

 
K6 __MTAIIKEIVSRNK
K13 KEIVSRNKRRYQEDG
Y27 GFDLDLTYIYPNIIA
Y46‑p AERLEGVyRNNIDDV
K66‑ub SKHKNHYkIYNLCAE
Y68 HKNHYkIYNLCAERH
K80‑ub ERHYDTAkFNCRVAQ
S113 EDLDQWLSEDDNHVA
K125 HVAAIHCKAGKGRTG
K128 AIHCKAGKGRTGVMI
Y138 TGVMICAYLLHRGKF
Y155 AQEALDFYGEVRTRD
K163 GEVRTRDKKGVTIPS
K164 EVRTRDKKGVTIPSQ
Y174‑p TIPSQRRyVyyySYL
Y176‑p PSQRRyVyyySYLLK
Y177‑p SQRRyVyyySYLLKN
Y178‑p QRRyVyyySYLLKNH
S179 RRyVyyySYLLKNHL
Y180 RyVyyySYLLKNHLD
S227 LKVKIYSSNSGPTRR
S229 VKIYSSNSGPTRRED
T232 YSSNSGPTRREDKFM
Y240 RREDKFMYFEFPQPL
K254 LPVCGDIKVEFFHKQ
K266 HKQNKMLKKDKMFHF
K266 HKQNKMLKKDKMFHF
K289 GPEETSEKVENGsLC
K289 GPEETSEKVENGsLC
S294‑p SEKVENGsLCDQEID
Y315 RADNDKEYLVLTLTK
T319 DKEYLVLTLTKNDLD
K332 LDKANKDKANRYFSP
Y336 NKDKANRYFSPNFKV
S362 SNPEASSSTSVtPDV
T366‑p ASSSTSVtPDVsDNE
S370‑p TSVtPDVsDNEPDHY
Y377 sDNEPDHYRYsDttD
S380‑p EPDHYRYsDttDsDP
T382‑p DHYRYsDttDsDPEN
T383‑p HYRYsDttDsDPENE
S385‑p RYsDttDsDPENEPF
S398 PFDEDQHSQITKV__
T401 EDQHSQITKV_____
K402 DQHSQITKV______
7960 : Non-phospho PTEN (Ser380/Thr382/Thr383) (D2D11) Rabbit mAb
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9551 : Phospho-PTEN (Ser380) Antibody
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
7960 : Non-phospho PTEN (Ser380/Thr382/Thr383) (D2D11) Rabbit mAb
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
7960 : Non-phospho PTEN (Ser380/Thr382/Thr383) (D2D11) Rabbit mAb
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
  rat

 
K6 __MTAIIKEIVSRNK
K13 KEIVSRNKRRYQEDG
Y27 GFDLDLTYIYPNIIA
Y46 AERLEGVYRNNIDDV
K66 SKHKNHYKIYNLCAE
Y68 HKNHYKIYNLCAERH
K80 ERHYDTAKFNCRVAQ
S113‑p EDLDQWLsEDDNHVA
K125 HVAAIHCKAGKGRTG
K128 AIHCKAGKGRTGVMI
Y138 TGVMICAYLLHRGKF
Y155 AQEALDFYGEVRTRD
K163 GEVRTRDKKGVTIPS
K164 EVRTRDKKGVTIPSQ
Y174 TIPSQRRYVYYYSYL
Y176 PSQRRYVYYYSYLLK
Y177 SQRRYVYYYSYLLKN
Y178 QRRYVYYYSYLLKNH
S179 RRYVYYYSYLLKNHL
Y180 RYVYYYSYLLKNHLD
S227 LKVKIYSSNSGPTRR
S229 VKIYSSNSGPTRRED
T232 YSSNSGPTRREDKLM
Y240 RREDKLMYFEFPQPL
K254 LPVCGDIKVEFFHKQ
K266‑ac HKQNKMLkKDKMFHF
K266 HKQNKMLKKDKMFHF
K289 GPEETSEKVENGSLC
K289 GPEETSEKVENGSLC
S294 SEKVENGSLCDQEID
Y315 RADNDKEYLVLtLTK
T319‑p DKEYLVLtLTKNDLD
K332 LDKANKDKANRYFSP
Y336 NKDKANRYFSPNFKV
S362 SNPEASSSTSVTPDV
T366 ASSSTSVTPDVSDNE
S370 TSVTPDVSDNEPDHY
Y377 SDNEPDHYRYsDTtD
S380‑p EPDHYRYsDTtDsDP
T382 DHYRYsDTtDsDPEN
T383‑p HYRYsDTtDsDPENE
S385‑p RYsDTtDsDPENEPF
S398 PFDEDQHSQITKV__
T401 EDQHSQITKV_____
K402 DQHSQITKV______
7960 : Non-phospho PTEN (Ser380/Thr382/Thr383) (D2D11) Rabbit mAb
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9551 : Phospho-PTEN (Ser380) Antibody
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
7960 : Non-phospho PTEN (Ser380/Thr382/Thr383) (D2D11) Rabbit mAb
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
7960 : Non-phospho PTEN (Ser380/Thr382/Thr383) (D2D11) Rabbit mAb
9549 : Phospho-PTEN (Ser380/Thr382/383) (44A7) Rabbit mAb
9554 : Phospho-PTEN (Ser380/Thr382/383) Antibody
9569 : Non-Phospho PTEN (Ser380/Thr382/Thr383) Antibody
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