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Protein Page:
H2A.4 (human)

Overview
H2A.4 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6p22.2
Cellular Component: nuclear chromatin; nuclear chromosome, telomeric region; nucleus
Molecular Function: DNA binding
Biological Process: chromatin silencing
Reference #:  Q96QV6 (UniProtKB)
Alt. Names/Synonyms: bA317E16.2; H2A histone family, member R; H2A1A; H2AFR; HIST1H2AA; histone 1, H2aa; histone cluster 1, H2aa; Histone H2A type 1-A; Histone H2A/r
Gene Symbols: HIST1H2AA
Molecular weight: 14,102 Da
Basal Isoelectric point: 10.86  Predict pI for various phosphorylation states
Select Structure to View Below

H2A.4

Protein Structure Not Found.
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