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Protein Page:
PR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PR a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 11q22-q23
Cellular Component: nucleoplasm
Molecular Function: ATPase binding; DNA binding; enzyme binding; protein binding
Biological Process: cell-cell signaling; positive regulation of transcription from RNA polymerase II promoter; signal transduction; transcription initiation from RNA polymerase II promoter
Disease: Progesterone Resistance
Reference #:  P06401 (UniProtKB)
Alt. Names/Synonyms: NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PRGR; Progesterone receptor
Gene Symbols: PGR
Molecular weight: 98,981 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PR

Protein Structure Not Found.
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Sites Implicated In
cell adhesion, altered: S294‑p
cell growth, altered: S294‑p, K388‑sm
transcription, induced: S81‑p, S102‑p, S162‑p, K183‑ac, S190‑p, S294‑p, S345‑p, S400‑p, S676‑p
transcription, inhibited: K388‑sm
intracellular localization: S294‑p
molecular association, regulation: S81‑p, K183‑ac, S345‑p
phosphorylation: K183‑ac
protein degradation: S294‑p
sumoylation: S294‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 K7‑sm _MTELKAkGPRAPHV
0 2 S20‑p HVAGGPPsPEVGsPL
0 1 S25‑p PPsPEVGsPLLCRPA
5 1 S81‑p TQDQQSLsDVEGAys
0 1 Y87‑p LsDVEGAysRAEATR
0 1 S88‑p sDVEGAysRAEATRG
2 1 S102‑p GAGGSSSsPPEKDSG
0 1 S130‑p GPGQSQPsPPACEVT
5 4 S162‑p PATQRVLsPLMSRSG
1 1 K183‑ac SGTAAAHkVLPRGLs
0 2 K183‑ub SGTAAAHkVLPRGLs
6 1 S190‑p kVLPRGLsPARQLLL
1 0 S213‑p SGAPVKPsPQAAAVE
1 0 S227 EVEEEDGSESEESAG
1 0 S276 PKEDSRFSAPRVALV
20 0 S294‑p APMAPGRsPLATTVM
1 0 S328 RQLLEDESYDGGAGA
6 1 S345‑p AFAPPRSsPCASSTP
1 0 K388‑ub QPPALKIkEEEEGAE
8 0 K388‑sm QPPALKIkEEEEGAE
8 0 S400‑p GAEASARsPRSYLVA
1 0 K464‑m1 TLECILYkAEGAPPQ
1 0 K531‑sm GYQAAVLkEGLPQVY
1 0 S549‑p LNYLRPDsEAsQsPQ
1 0 S552‑p LRPDsEAsQsPQYsF
2 0 S554‑p PDsEAsQsPQYsFEs
2 0 S558‑p AsQsPQYsFEsLPQK
1 0 S561‑p sPQYsFEsLPQKICL
2 1 S676‑p LSQRFTFsPGQDIQL
0 1 S846 TQFEEMRSSYIRELI
0 1 S847 QFEEMRSSYIRELIK
0 1 Y848 FEEMRSSYIRELIKA
3171 : Phospho-Progesterone Receptor (Ser190) Antibody
13736 : Phospho-Progesterone Receptor (Ser294) Antibody
12783 : Phospho-Progesterone Receptor (Ser345) Antibody
  PR iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K19 SGTAAAHKVLPRGLs
K19 SGTAAAHKVLPRGLs
S26‑p KVLPRGLsPARQLLL
S49 SGAPVKPSPQAAAVE
S63‑p EVEEEDGsESEESAG
S112‑p PKEDSRFsAPRVALV
S130‑p APMAPGRsPLATTVM
S164‑p RQLLEDEsYDGGAGA
S181 AFAPPRSSPCASSTP
K224 QPPALKIKEEEEGAE
K224 QPPALKIKEEEEGAE
S236‑p GAEASARsPRSYLVA
K300 TLECILYKAEGAPPQ
K367 GYQAAVLKEGLPQVY
S385 LNYLRPDSEASQsPQ
S388 LRPDSEASQsPQYsF
S390‑p PDSEASQsPQYsFES
S394‑p ASQsPQYsFESLPQK
S397 sPQYsFESLPQKICL
S512‑p LSQRFTFsPGQDIQL
S682 TQFEEMRSSYIRELI
S683 QFEEMRSSYIRELIK
Y684 FEEMRSSYIRELIKA
13736 : Phospho-Progesterone Receptor (Ser294) Antibody
  mouse

 
K7 _MTELQAKDPQVLHT
S20 HTSGASPSPPHIGSP
S26 PSPPHIGSPLLARLD
S82 TGDQQSLSDVEGAFS
F88 LSDVEGAFSGVEATH
S89 SDVEGAFSGVEATHR
R103 REGGRNSRPPEKDSR
S131 GPEQSHASPPACEAI
S163 PATKGLLSPLMSRPE
K184 SGTGRGQKVLPKGLS
K184 SGTGRGQKVLPKGLS
S191 KVLPKGLSPPRQLLL
S214 PGAGVKPSPQPAAGE
L228 EVEEDSGLETEGSAS
S277 PKEDSRFSAPRVSLE
S294‑p SPIAPGRsPLATTVV
S328 RQLLEGESYDGGATA
S343 GPFCPPRSPSAPSTP
K386 QTPGLKIKEEEEGAD
K386 QTPGLKIKEEEEGAD
S398 GADAAVRSPRPYLSA
K459 ALECILYKAEAPPTQ
K521 GYQAAVLKDSLPQVY
S539 LNYLRPDSEASQSPQ
S542 LRPDSEASQSPQYGF
S544 PDSEASQSPQYGFDS
G548 ASQSPQYGFDSLPQK
S551 SPQYGFDSLPQKICL
S666 LSQRITFSPNQEIQL
S836‑p SQFEEMRssyIRELI
S837‑p QFEEMRssyIRELIK
Y838‑p FEEMRssyIRELIKA
13736 : Phospho-Progesterone Receptor (Ser294) Antibody
  rat

 
K7 _MTELQAKDPRTLHT
S20 HTSGAAPSPTHVGSP
S26 PSPTHVGSPLLARLD
S82 TQNQQSLSDVEGAFS
F88 LSDVEGAFSGVEASR
S89 SDVEGAFSGVEASRR
R102 RRRSRNPRAPEKDSR
S130 GPEQSQTSPPACEAI
S162 PATKGLLSPLMSRPE
K183 SGTGAGQKVLPKAVS
K183 SGTGAGQKVLPKAVS
S190 KVLPKAVSPPRQLLL
S213 PGAGVKPSQQPATVE
L227 EVEEDGGLETEGSAG
S276 PKEDSRFSAPRVSLE
S293 APVAPGRSPLATTVV
S327 RQLLEGDSYDGGAAA
S344 PFAPPRGSPSAPSPP
K387 QPPGLKIKEEEEGTE
K387 QPPGLKIKEEEEGTE
S399 GTEAASRSPRPYLLA
K458 ALECILYKAEGAPPT
K521 GYQAAVLKDSLPQVY
S539 LNYLRPDSEASQSPQ
S542 LRPDSEASQSPQYGF
S544 PDSEASQSPQYGFDS
G548 ASQSPQYGFDSLPQK
S551 SPQYGFDSLPQKICL
S666 LGQRITFSPNQEIQL
S836 SQFEEMRSSYIRELI
S837 QFEEMRSSYIRELIK
Y838 FEEMRSSYIRELIKA
13736 : Phospho-Progesterone Receptor (Ser294) Antibody
  chicken

 
K7 _MTEVKSKETRAPSS
S13 SKETRAPSSARDGAV
A19 PSSARDGAVLLQAPP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S176 RPGPEDASENRAPGL
- gap
- gap
- gap
S259 SAFGPRSSPSVPAAD
K294 FQSALKIKEEGVGLP
K294 FQSALKIKEEGVGLP
- gap
K335 SLECVLYKAEPPLLP
K385 GFPAAVLKEGLPQLC
T403 LGYVRPDTETSQSSQ
S406 VRPDTETSQSSQYSF
S408 PDTETSQSSQYSFES
S412 TSQSSQYSFESLPQK
S415 SSQYSFESLPQKICL
S529 LTQRLSFSPNQEIPF
T699 SQFDEMRTSYIRELV
S700 QFDEMRTSYIRELVK
Y701 FDEMRTSYIRELVKA
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