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Protein Page:
PLCG1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PLCG1 a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate; Phospholipase; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 20q12-q13.1
Cellular Component: cell projection; cytoplasm; cytosol; lamellipodium; plasma membrane; ruffle; signalosome
Molecular Function: neurotrophin TRKA receptor binding; phosphoinositide phospholipase C activity; phospholipase C activity; protein binding; protein kinase binding
Biological Process: activation of MAPKK activity; calcium-mediated signaling; cell migration; epidermal growth factor receptor signaling pathway; inositol phosphate metabolic process; leukocyte migration; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of release of sequestered calcium ion into cytosol; signal transduction; T cell receptor signaling pathway
Reference #:  P19174 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; NCKAP3; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1; phospholipase C, gamma 1 (formerly subtype 148); phospholipase C-148; Phospholipase C-gamma-1; Phospholipase C-II; PLC-148; PLC-gamma-1; PLC-II; PLC1; PLC148; PLCG1; PLCgamma1; triphosphoinositide phosphodiesterase
Gene Symbols: PLCG1
Molecular weight: 148,532 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Phospholipase Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLCG1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
cell motility, altered: Y783‑p
enzymatic activity, induced: Y783‑p
intracellular localization: Y783‑p, Y1253‑p
molecular association, regulation: Y783‑p
phosphorylation: Y783‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 4 S6‑p __MAGAAsPCANGCG
0 1 K54‑ub ERKTFQVkLETRQIT
0 1 Y93‑p TSRDFDRyQEDPAFR
0 1 K175 REDRISAKDLkNMLS
0 3 K178‑ub RISAKDLkNMLSQVN
0 4 Y186‑p NMLSQVNyRVPNMRF
0 10 Y210‑p QRSGDITyGQFAQLY
0 2 Y217 yGQFAQLYRsLMYSA
0 1 S219‑p QFAQLYRsLMYSAQk
0 3 K226‑ub sLMYSAQkTMDLPFL
0 1 S236‑p DLPFLEAstLRAGER
0 2 T237‑p LPFLEAstLRAGERP
0 10 Y379‑p PDGMPVIyHGHTLTT
0 1 K389‑ub HTLTTKIkFSDVLHT
0 1 S412‑p SEYPVILsIEDHCSI
0 7 Y428‑p QQRNMAQyFKkVLGD
0 3 K431‑ub NMAQyFKkVLGDTLL
0 4 K440‑ub LGDTLLTkPVEISAD
0 1 S451‑p ISADGLPsPNQLKRK
0 11 S470‑p HKKLAEGsAyEEVPt
3 113 Y472‑p KLAEGsAyEEVPtSM
0 1 T477‑p sAyEEVPtSMMySEN
0 69 Y481‑p EVPtSMMySENDISN
0 4 Y496‑p SIKNGILyLEDPVNH
0 31 Y506‑p DPVNHEWyPHyFVLT
3 8 Y509‑p NHEWyPHyFVLTSSK
0 4 Y518‑p VLTSSKIyYSEETSs
0 3 S525‑p yYSEETSsDQGNEDE
0 1 S539‑p EEEPKEVsSStELHS
0 1 T542‑p PKEVsSStELHSNEK
0 1 Y669‑p AHESKEWyHASLTRA
0 10 Y702‑p KRNEPNSyAISFRAE
0 2 T766‑p EALEKIGtAEPdyGA
0 1 D770‑ca KIGtAEPdyGALyEG
14 569 Y771‑p IGtAEPdyGALyEGR
2 369 Y775‑p EPdyGALyEGRNPGF
68 564 Y783‑p EGRNPGFyVEANPMP
0 2 T791‑p VEANPMPtFKCAVKA
0 9 Y833‑p GGWWRGDyGGKKQLW
0 3 K941‑ub DARLTEGkIMERRKK
0 1 S954‑p KKIALELsELVVyCR
0 38 Y959‑p ELsELVVyCRPVPFD
0 664 Y977‑p IGTERACyRDMssFP
0 3 S981‑p RACyRDMssFPETKA
0 1 S982‑p ACyRDMssFPETKAE
0 9 Y991‑p PETKAEKyVNKAKGK
1 25 Y1003‑p KGKKFLQyNRLQLSR
0 1 K1079‑ub EAFDPFDkSSLRGLE
0 1 K1193‑ub GYRAVPLkNNYSEDL
0 1 K1215 KIDIFPAKENGDLsP
0 78 S1221‑p AKENGDLsPFsGtsL
0 5 S1224‑p NGDLsPFsGtsLRER
0 5 T1226‑p DLsPFsGtsLRERGs
0 32 S1227‑p LsPFsGtsLRERGsD
0 37 S1233‑p tsLRERGsDAsGQLF
0 7 S1236‑p RERGsDAsGQLFHGR
0 1 G1237 ERGsDAsGQLFHGRA
3 256 S1248‑p HGRAREGsFEsRyQQ
0 15 S1251‑p AREGsFEsRyQQPFE
12 78 Y1253‑p EGsFEsRyQQPFEDF
0 60 S1263‑p PFEDFRIsQEHLADH
0 2 S1273‑p HLADHFDsRERRAPR
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
14008 : Phospho-PLC gamma1 (Tyr783) (D6M9S) Rabbit mAb
14461 : Phospho-PLCgamma1 (Tyr783) (D6M9S) Rabbit mAb (PE Conjugate)
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
13349 : Phospho-PLC gamma1 (Ser1248) (D25A9) Rabbit mAb (PE Conjugate)
  PLCG1 iso2  
S6 __MAGAASPCANGCG
K54 ERKTFQVKLETRQIT
Y93 TSRDFDRYQEDPAFR
K175 REDRISAKDLKNMLS
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRSGDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
S219 QFAQLYRSLMYSAQK
K226 SLMYSAQKTMDLPFL
S236 DLPFLEASTLRAGER
T237 LPFLEASTLRAGERP
Y379 PDGMPVIYHGHTLTT
K389 HTLTTKIKFSDVLHT
S412 SEYPVILSIEDHCSI
Y428 QQRNMAQYFKKVLGD
K431 NMAQYFKKVLGDTLL
K440 LGDTLLTKPVEISAD
S451 ISADGLPSPNQLKRK
S470 HKKLAEGSAYEEVPT
Y472 KLAEGSAYEEVPTSM
T477 SAYEEVPTSMMYSEN
Y481 EVPTSMMYSENDISN
Y496 SIKNGILYLEDPVNH
Y506 DPVNHEWYPHYFVLT
Y509 NHEWYPHYFVLTSSK
Y518 VLTSSKIYYSEETSS
S525 YYSEETSSDQGNEDE
S539 EEEPKEVSSSTELHS
T542 PKEVSSSTELHSNEK
Y669 AHESKEWYHASLTRA
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDYGA
D770 KIGTAEPDYGALYEG
Y771 IGTAEPDYGALYEGR
Y775 EPDYGALYEGRNPGF
Y783 EGRNPGFYVEANPMP
T791 VEANPMPTFKCAVKA
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKIMERRKK
S954 KKIALELSELVVYCR
Y959 ELSELVVYCRPVPFD
Y977 IGTERACYRDMSSFP
S981 RACYRDMSSFPETKA
S982 ACYRDMSSFPETKAE
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1079 EAFDPFDKSSLRGLE
K1193 GYRAVPLKNNYSEDL
K1215 KIDIFPAKQENGDLs
S1222‑p KQENGDLsPFsGtsL
S1225‑p NGDLsPFsGtsLRER
T1227‑p DLsPFsGtsLRERGs
S1228‑p LsPFsGtsLRERGsD
S1234‑p tsLRERGsDAsGQLF
S1237‑p RERGsDAsGQLFHGR
G1238 ERGsDAsGQLFHGRA
S1249 HGRAREGSFESRYQQ
S1252 AREGSFESRYQQPFE
Y1254 EGSFESRYQQPFEDF
S1264 PFEDFRISQEHLADH
S1274 HLADHFDSRERRAPR
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
  mouse

 
T6 __MAGVATPCANGCG
K54 ERKTFQVKLETRQIT
Y93 TSRDFDRYQEDPAFR
K175 REDRISAKDLkNMLS
K178‑ub RISAKDLkNMLSQVN
Y186‑p NMLSQVNyRVPNMRF
Y210‑p QRSGDITyGQFAQLy
Y217‑p yGQFAQLyRSLMYSA
S219 QFAQLyRSLMYSAQk
K226‑ub SLMYSAQkTMDLPFL
N236 DLPFLETNALRTGER
A237 LPFLETNALRTGERP
Y379‑p PDGMPVIyHGHTLTT
K389 HTLTTKIKFSDVLHT
S412 SEYPVILSIEDHCSI
H428 QQRNMAQHFRkVLGD
K431‑ub NMAQHFRkVLGDTLL
K440‑ub LGDTLLTkPVDIAAD
S451 IAADGLPSPNQLRRK
S470 HKKLAEGSAyEEVPT
Y472‑p KLAEGSAyEEVPTSV
T477 SAyEEVPTSVMySEN
Y481‑p EVPTSVMySENDISN
Y496‑p SIKNGILyLEDPVNH
Y506‑p DPVNHEWyPHyFVLT
Y509‑p NHEWyPHyFVLTSSK
Y518 VLTSSKIYYSEETSS
S525 YYSEETSSDQGNEDE
S539 EEEPKEASSSTELHS
T542 PKEASSSTELHSSEK
Y669 AHESKEWYHASLTRA
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDyGA
D770 KIGTAEPDyGALyEG
Y771‑p IGTAEPDyGALyEGR
Y775‑p EPDyGALyEGRNPGF
Y783‑p EGRNPGFyVEANPMP
T791 VEANPMPTFKCAVKA
Y833 GGWWRGDYGGKKQLW
K941‑ub DARLTEGkMMERRKK
S954 KKIALELSELVVYCR
Y959 ELSELVVYCRPVPFD
Y977‑p IGTERACyRDMSSFP
S981 RACyRDMSSFPETKA
S982 ACyRDMSSFPETKAE
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1079 EAFDPFDKSSLRGLE
K1193 GYRAVPLKNNYSEDL
K1215‑ub KIDIFPAkENGDLsP
S1221‑p AkENGDLsPFsGIsL
S1224‑p NGDLsPFsGIsLRER
I1226 DLsPFsGIsLRERAs
S1227‑p LsPFsGIsLRERAsD
S1233‑p IsLRERAsDAssQLF
S1236‑p RERAsDAssQLFHVR
S1237‑p ERAsDAssQLFHVRA
S1248‑p HVRAREGsFEARyQQ
A1251 AREGsFEARyQQPFE
Y1253‑p EGsFEARyQQPFEDF
S1263‑p PFEDFRIsQEHLADH
S1273 HLADHFDSRERSTSD
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
14008 : Phospho-PLC gamma1 (Tyr783) (D6M9S) Rabbit mAb
14461 : Phospho-PLCgamma1 (Tyr783) (D6M9S) Rabbit mAb (PE Conjugate)
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
13349 : Phospho-PLC gamma1 (Ser1248) (D25A9) Rabbit mAb (PE Conjugate)
  rat

 
T6 __MAGVGTPCANGCG
K54 ERKTFQVKLETRQIT
Y93 TSRDFDRYQEDPAFR
K175‑ac REDRISAkDLKNMLS
K178 RISAkDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRSGDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
S219 QFAQLYRSLMYSAQK
K226 SLMYSAQKTMDLPFL
N236 DLPFLETNTLRTGER
T237 LPFLETNTLRTGERP
Y379‑p PDGMPVIyHGHTLTT
K389 HTLTTKIKFSDVLHT
S412 SEYPVILSIEDHCSI
H428 QQRNMAQHFRKVLGD
K431 NMAQHFRKVLGDTLL
K440 LGDTLLTKPVDIAAD
S451 IAADGLPSPNQLKRK
S470 HKKLAEGSAYEEVPT
Y472 KLAEGSAYEEVPTSV
T477 SAYEEVPTSVMySEN
Y481‑p EVPTSVMySENDISN
Y496 SIKNGILYLEDPVNH
Y506‑p DPVNHEWyPHyFVLT
Y509‑p NHEWyPHyFVLTSSK
Y518 VLTSSKIYYSEETSS
S525 YYSEETSSDQGNEDE
S539 EEEPKEASGSTELHS
T542 PKEASGSTELHSSEK
Y669 AHESKEWYHASLTRA
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDyGA
D770 KIGTAEPDyGALyEG
Y771‑p IGTAEPDyGALyEGR
Y775‑p EPDyGALyEGRNPGF
Y783‑p EGRNPGFyVEANPMP
T791 VEANPMPTFKCAVKA
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKMMERRKK
S954 KKIALELSELVVYCR
Y959 ELSELVVYCRPVPFD
Y977‑p IGTERACyRDMSSFP
S981 RACyRDMSSFPETKA
S982 ACyRDMSSFPETKAE
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1079 EAFDPFDKSSLRGLE
K1193 GYRAVPLKNNYSEDL
K1215 KIDIFPAKENGDLsP
S1221‑p AKENGDLsPFSGTSL
S1224 NGDLsPFSGTSLRER
T1226 DLsPFSGTSLRERAS
S1227 LsPFSGTSLRERASD
S1233 TSLRERASDASSQLF
S1236 RERASDASSQLFHVR
S1237 ERASDASSQLFHVRA
S1248‑p HVRAREGsFEARyQQ
A1251 AREGsFEARyQQPFE
Y1253‑p EGsFEARyQQPFEDF
S1263 PFEDFRISQEHLADH
S1273 HLADHFDSRERRAPR
2824 : Phospho-PLCgamma1 (Tyr771) Antibody
2821 : Phospho-PLCgamma1 (Tyr783) Antibody
14008 : Phospho-PLC gamma1 (Tyr783) (D6M9S) Rabbit mAb
14461 : Phospho-PLCgamma1 (Tyr783) (D6M9S) Rabbit mAb (PE Conjugate)
4510 : Phospho-PLCgamma1 (Ser1248) Antibody
8713 : Phospho-PLC gamma 1 (Ser1248) (D25A9) Rabbit mAb
13349 : Phospho-PLC gamma1 (Ser1248) (D25A9) Rabbit mAb (PE Conjugate)
  cow

 
S6 __MAGAASPCANGCG
K54 ERKTFQVKLETRQIT
Y93 TSRDFDRYQEDPAFR
K175 REDRISAKDLKNMLS
K178 RISAKDLKNMLSQVN
Y186 NMLSQVNYRVPNMRF
Y210 QRTSDITYGQFAQLY
Y217 YGQFAQLYRSLMYSA
S219 QFAQLYRSLMYSAQK
K226 SLMYSAQKTMDLPFL
S236 DLPFLEASALRAGER
A237 LPFLEASALRAGERP
Y379 PDGMPVIYHGHTLTT
K389 HTLTTKIKFSDVLHT
S412 SEYPVILSIEDHCSI
Y428 QQRNMAQYFKKVLGD
K431 NMAQYFKKVLGDTLL
K440 LGDTLLTKPVDIAAD
S451 IAADGLPSPNQLKRK
S470 HKKLAEGSAyEEVPT
Y472‑p KLAEGSAyEEVPTSV
T477 SAyEEVPTSVMYSEN
Y481 EVPTSVMYSENDISN
Y496 SIKNGILYLEDPVNH
Y506 DPVNHEWYPHyFVLT
Y509‑p NHEWYPHyFVLTSSK
Y518 VLTSSKIYYSEETSS
S525 YYSEETSSDQGNEDE
S539 EEEPKEASGSTELHS
T542 PKEASGSTELHSNEK
Y669 AHESKEWYHASLTRA
Y702 KRNEPNSYAISFRAE
T766 EALEKIGTAEPDyGA
D770 KIGTAEPDyGALyEG
Y771‑p IGTAEPDyGALyEGR
Y775‑p EPDyGALyEGRNPGF
Y783‑p EGRNPGFyVEANPMP
T791 VEANPMPTFKCAVKA
Y833 GGWWRGDYGGKKQLW
K941 DARLTEGKMMERRKK
S954 KKIALELSELVVYCR
Y959 ELSELVVYCRPVPFD
Y977 IGTERACYRDMSSFP
S981 RACYRDMSSFPETKA
S982 ACYRDMSSFPETKAE
Y991 PETKAEKYVNKAKGK
Y1003 KGKKFLQYNRLQLSR
K1079 EAFDPFDKSSLRGLE
K1193 GYRAVPLKNNYSEGL
K1215 KIDVFPAKQENGDLS
S1222 KQENGDLSPFGGASL
G1225 NGDLSPFGGASLRER
A1227 DLSPFGGASLRERSC
S1228 LSPFGGASLRERSCD
C1234 ASLRERSCDASGPLF
S1237 RERSCDASGPLFHGR
G1238 ERSCDASGPLFHGRA
S1249 HGRAREGSFEARyQQ
A1252 AREGSFEARyQQPFE
Y1254‑p EGSFEARyQQPFEDF
S1264 PFEDFRISQEHLADH
G1274 HLADHFDGRDRRTPR
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