Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5- ATG12 conjugate. By apoptotic stimuli. Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. Belongs to the ATG5 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Apoptosis; Ubiquitin conjugating system
Molecular Function: APG8 conjugating enzyme activity; protein binding
Biological Process: antigen processing and presentation of endogenous antigen; apoptosis; autophagic vacuole formation; autophagy; blood vessel remodeling; C-terminal protein lipidation; cellular homeostasis; cellular response to nitrogen starvation; heart contraction; innate immune response; macroautophagy; mitochondrion degradation; negative regulation of apoptosis; negative regulation of protein ubiquitination; negative thymic T cell selection; otolith development; post-translational protein modification; regulation of cytokine secretion during immune response; regulation of release of sequestered calcium ion into cytosol; response to drug; response to fungus; vasodilation; ventricular cardiac muscle cell development
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.