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Protein Page:
PDGFRA (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PDGFRA a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation. Particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. Chromosomal rearrangments activate PDGFRalpha by fusion to BCR, causing atypical chronic myelogenous leukemia (CML), and to FIP1L1, causing idiopathic hypereosinophilic syndrome. Activating point mutations cause a minority of gastrointestinal stromal tumors (GIST). Promoter polymorphisms linked to neural tube defects including spina bifida, verified by mouse mutant model. Inhibitors: Gleevec, Sutent. OMIM: Two alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); Oncoprotein; Kinase, protein; EC 2.7.10.1; Protein kinase, TK; TK group; PDGFR family
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: cytoplasm; cytosol; integral to plasma membrane; intrinsic to plasma membrane; membrane; nucleus; plasma membrane; protein complex
Molecular Function: ATP binding; platelet-derived growth factor alpha-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein binding; protein homodimerization activity; protein kinase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor receptor activity
Biological Process: activation of MAPKK activity; axon guidance; cardiac myofibril assembly; cell activation; elevation of cytosolic calcium ion concentration; embryonic cranial skeleton morphogenesis; embryonic digestive tract morphogenesis; embryonic skeletal morphogenesis; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; luteinization; MAPKKK cascade; nerve growth factor receptor signaling pathway; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of fibroblast proliferation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; protein amino acid autophosphorylation; Ras protein signal transduction; regulation of chemotaxis; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway; viral reproduction; wound healing
Disease: Gastrointestinal Stromal Tumor; Hypereosinophilic Syndrome, Idiopathic
Reference #:  P16234 (UniProtKB)
Alt. Names/Synonyms: Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140A; CD140a antigen; MGC74795; PDGF-R-alpha; PDGFR2; PDGFRA; PGFRA; platelet-derived growth factor receptor, alpha polypeptide; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; RHEPDGFRA
Gene Symbols: PDGFRA
Molecular weight: 122,670 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PDGFRA

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y572‑p, Y574‑p, Y720‑p, Y731‑p, Y742‑p, Y754‑p, Y762‑p, Y988‑p, Y1018‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K378‑m1 QEIRYRSkLKLIRAK
0 2 S566‑p WRVIESIsPDGHEyI
2 21 Y572‑p IsPDGHEyIyVDPMQ
2 16 Y574‑p PDGHEyIyVDPMQLP
0 9 Y582‑p VDPMQLPyDsRWEFP
0 2 S584‑p PMQLPyDsRWEFPRD
0 1 K606 LGSGAFGKVVEGTAy
0 48 Y613‑p KVVEGTAyGLSRSQP
0 1 K703 HHPEKPKKELDIFGL
0 1 S716‑p GLNPADEstRSyVIL
0 1 T717‑p LNPADEstRSyVILS
0 1 S719 PADEstRSyVILSFE
5 5 Y720‑p ADEstRSyVILSFEN
1 35 Y731‑p SFENNGDyMDMKQAD
0 1 T739‑p MDMKQADttQyVPML
0 4 T740‑p DMKQADttQyVPMLE
1 107 Y742‑p KQADttQyVPMLERK
0 4 S752‑p MLERKEVsKysDIQR
0 1 K753 LERKEVsKysDIQRs
4 37 Y754‑p ERKEVsKysDIQRsL
0 6 S755‑p RKEVsKysDIQRsLy
0 4 S760‑p KysDIQRsLyDRPAs
2 328 Y762‑p sDIQRsLyDRPAsyK
1 12 S767‑p sLyDRPAsyKKKSML
1 268 Y768‑p LyDRPAsyKKKSMLD
0 16 S847‑p ARDIMHDsNyVSKGS
2 67 Y849‑p DIMHDsNyVSKGSTF
0 1 K852 HDsNyVSKGSTFLPV
0 6 Y926‑p DHATSEVyEIMVKCW
0 1 S935‑p IMVKCWNsEPEKRPS
0 2 Y944‑p PEKRPSFyHLSEIVE
0 4 Y958‑p ENLLPGQyKKSyEKI
0 5 Y962‑p PGQyKKSyEKIHLDF
0 1 K964 QyKKSyEKIHLDFLK
0 2 K971 KIHLDFLKSDHPAVA
0 2 S984 VARMRVDSDNAyIGV
3 22 Y988‑p RVDSDNAyIGVtyKN
0 1 T992‑p DNAyIGVtyKNEEDK
0 2 Y993‑p NAyIGVtyKNEEDKL
0 1 S1013 GLDEQRLSADsGyII
0 3 S1016‑p EQRLSADsGyIIPLP
4 99 Y1018‑p RLSADsGyIIPLPDI
0 1 K1036 PEEEDLGKRNRHssQ
0 1 S1041‑p LGKRNRHssQTSEEs
0 2 S1042‑p GKRNRHssQTSEEsA
0 1 S1048‑p ssQTSEEsAIETGSS
0 1 S1080‑p MDDIGIDssDLVEDs
0 1 S1081‑p DDIGIDssDLVEDsF
0 1 S1087‑p ssDLVEDsFL_____
2992 : Phospho-PDGF Receptor alpha (Tyr754) (23B2) Rabbit mAb
12022 : Phospho-PDGF Receptor alpha (Tyr762) Antibody
24188 : Phospho-PDGF Receptor alpha (Tyr762) (D9B1N) Rabbit mAb
3170 : Phospho-PDGF Receptor alpha (Tyr849)/PDGF Receptor beta (Tyr857) (C43E9) Rabbit mAb
4547 : Phospho-PDGFR alpha (Tyr1018) Antibody
  mouse

 
K378 QETRYQSKLKLIRAK
S566‑p WRVIESIsPDGHEyI
Y572‑p IsPDGHEyIyVDPMQ
Y574‑p PDGHEyIyVDPMQLP
Y582‑p VDPMQLPyDSRWEFP
S584 PMQLPyDSRWEFPRD
K606‑ub LGSGAFGkVVEGTAy
Y613‑p kVVEGTAyGLSRSQP
K703‑ub QHPEKPKkDLDIFGL
S716 GLNPADESTRsyVIL
T717 LNPADESTRsyVILS
S719‑p PADESTRsyVILSFE
Y720‑p ADESTRsyVILSFEN
Y731‑p SFENNGDyMDMKQAD
T739 MDMKQADTTQyVPML
T740 DMKQADTTQyVPMLE
Y742‑p KQADTTQyVPMLERK
S752‑p MLERKEVskysDIQR
K753‑ub LERKEVskysDIQRs
Y754‑p ERKEVskysDIQRsL
S755‑p RKEVskysDIQRsLy
S760‑p kysDIQRsLyDRPAs
Y762‑p sDIQRsLyDRPAsyK
S767‑p sLyDRPAsyKKKSML
Y768‑p LyDRPAsyKKKSMLD
S847‑p ARDIMHDsNyVSkGS
Y849‑p DIMHDsNyVSkGSTF
K852‑ub HDsNyVSkGSTFLPV
Y926 DHATSEVYEIMVQCW
S935 IMVQCWNSEPEKRPS
Y944 PEKRPSFYHLSEIVE
Y958 ENLLPGQYKKSYEkI
Y962 PGQYKKSYEkIHLDF
K964‑ub QYKKSYEkIHLDFLk
K971‑ub kIHLDFLkSDHPAVA
S984‑p VARMRVDsDNAyIGV
Y988‑p RVDsDNAyIGVTYKN
T992 DNAyIGVTYKNEEDK
Y993 NAyIGVTYKNEEDKL
S1013‑p GLDEQRLsADSGyII
S1016 EQRLsADSGyIIPLP
Y1018‑p RLsADSGyIIPLPDI
K1036‑ub PEEEDLGkRNRHSSQ
S1041 LGkRNRHSSQTSEES
S1042 GkRNRHSSQTSEESA
S1048 SSQTSEESAIETGSS
S1080 MDDIGIDSSDLVEDS
S1081 DDIGIDSSDLVEDSF
S1087 SSDLVEDSFL_____
2992 : Phospho-PDGF Receptor alpha (Tyr754) (23B2) Rabbit mAb
3170 : Phospho-PDGF Receptor alpha (Tyr849)/PDGF Receptor beta (Tyr857) (C43E9) Rabbit mAb
4547 : Phospho-PDGFR alpha (Tyr1018) Antibody
  rat

 
K377 QETRYQSKLKLIRAK
S565 WRVIESISPDGHEYI
Y571 ISPDGHEYIYVDPMQ
Y573 PDGHEYIYVDPMQLP
Y581 VDPMQLPYDSRWEFP
S583 PMQLPYDSRWEFPRD
K605 LGSGAFGKVVEGTAy
Y612‑p KVVEGTAyGLSRSQP
K702 RHPEKPKKDLDIFGL
S715 GLNPADESTRSYVIL
T716 LNPADESTRSYVILS
S718 PADESTRSYVILSFE
Y719 ADESTRSYVILSFEN
Y730 SFENNGDYVDMKQAD
T738 VDMKQADTTQYVPML
T739 DMKQADTTQYVPMLE
Y741 KQADTTQYVPMLERK
S751 MLERKEVSKYSDIQR
K752 LERKEVSKYSDIQRS
Y753 ERKEVSKYSDIQRSL
S754 RKEVSKYSDIQRSLY
S759 KYSDIQRSLYDRPAS
Y761 SDIQRSLYDRPASYK
S766 SLYDRPASYKKKSML
Y767 LYDRPASYKKKSMLD
S846 ARDIMHDSNYVSKGS
Y848 DIMHDSNYVSKGSTF
K851 HDSNYVSKGSTFLPV
Y925 DHATSEVYEIMVQCW
S934 IMVQCWNSEPEKRPS
Y943 PEKRPSFYHLSEIVE
Y957 ENLLPGQYKKSYEKI
Y961 PGQYKKSYEKIHLDF
K963 QYKKSYEKIHLDFLK
K970 KIHLDFLKSDHPAVA
S983 VARMRVDSDNAYIGV
Y987 RVDSDNAYIGVTYKN
T991 DNAYIGVTYKNEEDK
Y992 NAYIGVTYKNEEDKL
S1012 GLDEQRLSADSGYII
S1015 EQRLSADSGYIIPLP
Y1017 RLSADSGYIIPLPDI
K1035 PEEEDLGKRNRHSSQ
S1040 LGKRNRHSSQTSEES
S1041 GKRNRHSSQTSEESA
S1047 SSQTSEESAIETGSS
S1079 MDDIGIDSSDLVEDS
S1080 DDIGIDSSDLVEDSF
S1086 SSDLVEDSFL_____
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