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Protein Page:
PDE5A (human)

Overview
PDE5A a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A. Alternative splicing results in four transcript variants encoding distinct isoforms. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 4q27
Cellular Component: cytosol
Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; cGMP binding
Biological Process: cGMP catabolic process
Reference #:  O76074 (UniProtKB)
Alt. Names/Synonyms: CGB-PDE; cGMP-binding cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; CN5A; PDE5; PDE5A; PDE5A1; phosphodiesterase 5A, cGMP-specific
Gene Symbols: PDE5A
Molecular weight: 99,985 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PDE5A

Protein Structure Not Found.
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