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Protein Page:
p27Kip1 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
p27Kip1 a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. May mediate TGF beta-induced g1 arrest. Its degradation is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Cell cycle regulation; Protein kinase, regulatory subunit; Oncoprotein
Chromosomal Location of Human Ortholog: 12p13.1-p12
Cellular Component: cytoplasm; cytosol; endosome; nucleoplasm; nucleus
Molecular Function: caspase activator activity; chaperone binding; cyclin-dependent protein kinase inhibitor activity; Hsp70 protein binding; protein binding; protein complex binding; protein phosphatase binding; transforming growth factor beta receptor, cytoplasmic mediator activity
Biological Process: autophagic cell death; caspase activation; cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; G1/S transition of mitotic cell cycle; innate immune response; inner ear development; mitotic cell cycle; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of cell motility; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of kinase activity; negative regulation of mitotic cell cycle; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; Notch signaling pathway; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of cyclin-dependent protein kinase activity; positive regulation of microtubule polymerization; positive regulation of protein catabolic process; potassium ion transport; regulation of cyclin-dependent protein kinase activity; response to amino acid stimulus; response to cadmium ion; response to drug; response to estradiol stimulus; response to glucose stimulus; response to hypoxia; response to peptide hormone stimulus; sensory perception of sound; small GTPase mediated signal transduction
Disease: Multiple Endocrine Neoplasia, Type Iv
Reference #:  P46527 (UniProtKB)
Alt. Names/Synonyms: CDKN1B; CDKN4; CDN1B; Cyclin-dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor p27; KIP1; MEN1B; MEN4; p27Kip1
Gene Symbols: CDKN1B
Molecular weight: 22,073 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  G1/S Checkpoint  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

p27Kip1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S10‑p, T157‑p
cell adhesion, induced: S10‑p
cell cycle regulation: S10‑p, Y74‑p, Y88‑p, Y89‑p, T157‑p, T187‑p, T198‑p
cell growth, altered: T157‑p, T198‑p
cell motility, induced: S10‑p, T157‑p, T198‑p
cytoskeletal reorganization: S10‑p, T157‑p
transcription, altered: S10‑p
transcription, induced: T157‑p, T198‑p
activity, inhibited: Y88‑p, Y89‑p
intracellular localization: S10‑p, Y88‑p, Y89‑p, T157‑p, T198‑p
molecular association, regulation: S10‑p, Y74‑p, Y88‑p, Y89‑p, T157‑p, T187‑p, T198‑p
phosphorylation: S10‑p, T157‑p
protein conformation: S83‑p, T187‑p
protein degradation: S10‑p, Y74‑p, Y88‑p, T157‑p, T187‑p, T198‑p
protein stabilization: S10‑p, T187‑p, T198‑p
ubiquitination: T187‑p

Modification Sites and Domains  
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Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S7 _MSNVRVSNGsPSLE
43 27 S10‑p NVRVSNGsPSLErMD
1 2 S12 RVSNGsPSLErMDAR
0 1 R15‑m1 NGsPSLErMDARQAE
0 1 K25 ARQAEHPKPSACRNL
1 0 T42 PVDHEELTRDLEKHC
0 1 K59 MEEASQRKWNFDFQN
0 1 K68 NFDFQNHKPLEGKyE
7 0 Y74‑p HKPLEGKyEWQEVEk
0 1 K81‑ac yEWQEVEkGsLPEFy
2 0 S83‑p WQEVEkGsLPEFyyR
9 0 Y88‑p kGsLPEFyyRPPRPP
6 0 Y89‑p GsLPEFyyRPPRPPK
0 1 K100 RPPKGACKVPAQESQ
0 10 S106 CKVPAQESQDVSGSR
1 0 K134‑ub DTHLVDPkTDPSDsQ
0 3 S140‑p PkTDPSDsQTGLAEQ
1 0 K153‑ub EQCAGIRkrPAtDDS
0 1 R154‑m2 QCAGIRkrPAtDDSS
21 1 T157‑p GIRkrPAtDDSSTQN
1 0 K165‑ub DDSSTQNkRANRTEE
2 0 T170 QNkRANRTEENVSDG
1 0 S175 NRTEENVSDGsPNAG
5 7 S178‑p EENVSDGsPNAGsVE
1 1 S183‑p DGsPNAGsVEQtPKK
45 0 T187‑p NAGsVEQtPKKPGLR
24 6 T198‑p PGLRRRQt_______
  mouse

 
S7‑p _MSNVRVsNGsPsLE
S10‑p NVRVsNGsPsLERMD
S12‑p RVsNGsPsLERMDAR
R15 NGsPsLERMDARQAE
K25 ARQAEHPKPSACRNL
T42‑p PVNHEELtRDLEKHC
K59 MEEASQRKWNFDFQN
K68 NFDFQNHKPLEGRYE
Y74 HKPLEGRYEWQEVER
R81 YEWQEVERGsLPEFy
S83‑p WQEVERGsLPEFyYR
Y88‑p RGsLPEFyYRPPRPP
Y89 GsLPEFyYRPPRPPK
K100 RPPKSACKVLAQEsQ
S106‑p CKVLAQEsQDVSGSR
M134 DRHLVDQMPDSSDNP
N140 QMPDSSDNPAGLAEQ
K153 EQCPGMRKRPAAEDS
R154 QCPGMRKRPAAEDSS
A157 GMRKRPAAEDSSSQN
K165 EDSSSQNKRANRtEE
T170‑p QNKRANRtEENVsDG
S175‑p NRtEENVsDGsPNAG
S178‑p EENVsDGsPNAGtVE
T183‑p DGsPNAGtVEQtPKK
T187‑p NAGtVEQtPKKPGLR
T197‑p KPGLRRQt_______
  rat

 
S7 _MSNVRVSNGsPSLE
S10‑p NVRVSNGsPSLERMD
S12 RVSNGsPSLERMDAR
R15 NGsPSLERMDARQTE
K25‑ac ARQTEHPkPSACRNL
T42 PVNHEELTRDLEKHC
K59‑ac MEEASQRkWNFDFQN
K68‑ac NFDFQNHkPLEGRYE
Y74 HkPLEGRYEWQEVER
R81 YEWQEVERGSLPEFY
S83 WQEVERGSLPEFYYR
Y88 RGSLPEFYYRPPRPP
Y89 GSLPEFYYRPPRPPK
K100‑ac RPPKSACkVPAQEsL
S106‑p CkVPAQEsLDVSGSR
M134 DRHLVDQMPDSSDSP
S140 QMPDSSDSPAGLAEQ
K153 EQCPGMRKRPAAEDS
R154 QCPGMRKRPAAEDSS
A157 GMRKRPAAEDSSSQN
K165 EDSSSQNKRANRTEE
T170 QNKRANRTEENVSDG
S175 NRTEENVSDGsPNAG
S178‑p EENVSDGsPNAGTVE
T183 DGsPNAGTVEQTPKK
T187 NAGTVEQTPKKPGLR
T197 KPGLRRQT_______
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