a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. Its expression is tightly controlled by p53, through which this protein mediates the p53-dependent cell cycle arrest at G1 phase. Note: This description may include information from UniProtKB.
Cellular Component: cyclin-dependent protein kinase holoenzyme complex; cytosol; nucleolus; nucleoplasm; nucleus; protein complex
Molecular Function: cyclin-dependent protein kinase activating kinase activity; cyclin-dependent protein kinase inhibitor activity; protein binding; ubiquitin protein ligase binding
Biological Process: cell cycle arrest; cellular response to amino acid starvation; cellular response to extracellular stimulus; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of phosphorylation; positive regulation of fibroblast proliferation; positive regulation of protein kinase activity; protein stabilization; Ras protein signal transduction; regulation of cyclin-dependent protein kinase activity; response to DNA damage stimulus