Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
BAK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BAK1 In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. Interacts with BCL2A1. Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L). Interacts with myxoma virus protein M11L. Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle. Belongs to the Bcl-2 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Endoplasmic reticulum; Mitochondrial; Apoptosis
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: integral to mitochondrial outer membrane; mitochondrial outer membrane; mitochondrion; pore complex
Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: cytolysis; DNA damage response, signal transduction resulting in induction of apoptosis; endoplasmic reticulum calcium ion homeostasis; establishment and/or maintenance of transmembrane electrochemical gradient; positive regulation of apoptosis; positive regulation of proteolysis; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of protein heterodimerization activity; regulation of protein homodimerization activity; release of cytochrome c from mitochondria; unfolded protein response, activation of signaling protein activity
Reference #:  Q16611 (UniProtKB)
Alt. Names/Synonyms: Apoptosis regulator BAK; BAK; BAK-LIKE; BAK1; Bcl-2 homologous antagonist/killer; Bcl-2-like protein 7; BCL2-antagonist/killer 1; Bcl2-L-7; BCL2-like 7 protein; BCL2L7; CDN1; MGC117255; MGC3887; pro-apoptotic protein BAK
Gene Symbols: BAK1
Molecular weight: 23,409 Da
Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BAK1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Sites Implicated In
apoptosis, altered: Y108‑p
apoptosis, inhibited: Y108‑p
activity, inhibited: Y108‑p
protein conformation: Y108‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 P17 PRQECGEPALPSASE
0 2 S21 CGEPALPSASEEQVA
0 1 S23 EPALPSASEEQVAQD
2 1 Y108‑p QPTAENAyEyFTKIA
2 1 Y110‑p TAENAyEyFTKIATS
0 1 E120 KIATSLFESGINWGR
0 1 T148‑p HVYQHGLtGFLGQVT
  mouse

 
S17‑p PKVGCDEsPsPsEQQ
S19‑p VGCDEsPsPsEQQVA
S21‑p CDEsPsPsEQQVAQD
Y106 QPTAGNAYELFTKIA
L108 TAGNAYELFTKIASS
K118‑ub KIASSLFkSGISWGR
T146 YVYQRGLTGFLGQVT
  rat

 
A17 PKGDCDEALSASEQQ
S19 GDCDEALSASEQQVA
S21 CDEALSASEQQVAQD
Y106 QPTAGNAYELFTKIA
L108 TAGNAYELFTKIASS
K118 KIASSLFKSGISWGR
T146 YVYQRGLTGFLGQVT
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.