Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
PDGFA (human)

Overview
PDGFA Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Secreted, signal peptide; Cytokine; Secreted
Chromosomal Location of Human Ortholog: 7p22
Cellular Component: cell surface; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi membrane; microvillus
Molecular Function: collagen binding; growth factor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: actin cytoskeleton organization and biogenesis; activation of MAPKK activity; alveolus development; angiogenesis; axon guidance; blood coagulation; cell activation; cell projection biogenesis; cell-cell signaling; epidermal growth factor receptor signaling pathway; extracellular matrix organization and biogenesis; fibroblast growth factor receptor signaling pathway; gut development; hair follicle development; innate immune response; inner ear development; insulin receptor signaling pathway; MAPKKK cascade; negative chemotaxis; negative regulation of phosphatidylinositol biosynthetic process; nerve growth factor receptor signaling pathway; organ morphogenesis; phosphoinositide-mediated signaling; platelet activation; platelet degranulation; platelet-derived growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of fibroblast proliferation; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of protein kinase B signaling cascade; Ras protein signal transduction; regulation of actin cytoskeleton organization and biogenesis; regulation of peptidyl-tyrosine phosphorylation; regulation of smooth muscle cell migration; response to drug; response to estradiol stimulus; response to hypoxia; response to inorganic substance; response to retinoic acid; response to wounding; skin development; small GTPase mediated signal transduction; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; wound healing
Reference #:  P04085 (UniProtKB)
Alt. Names/Synonyms: PDGF A-chain; PDGF subunit A; PDGF-1; PDGF-A; PDGF1; PDGFA; Platelet-derived growth factor A chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein; Platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor subunit A
Gene Symbols: PDGFA
Molecular weight: 24,043 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
Select Structure to View Below

PDGFA

Protein Structure Not Found.


STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S108‑p VIYEIPRsQVDPtsA
0 1 T113‑p PRsQVDPtsANFLIW
0 1 S114‑p RsQVDPtsANFLIWP
0 1 S136‑p CTGCCNTssVKCQPS
0 1 S137‑p TGCCNTssVKCQPSR
  mouse

 
S108 VIYEIPRSQVDPTSA
T113 PRSQVDPTSANFLIW
S114 RSQVDPTSANFLIWP
S136 CTGCCNTSSVKCQPS
S137 TGCCNTSSVKCQPSR
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.