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Protein Page:
PDGFA (human)

Overview
PDGFA Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Cell cycle regulation; Secreted, signal peptide; Cytokine
Chromosomal Location of Human Ortholog: 7p22
Cellular Component: cell surface; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi membrane; microvillus
Molecular Function: collagen binding; growth factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: actin cytoskeleton organization and biogenesis; alveolus development; angiogenesis; cell activation; cell projection biogenesis; cell-cell signaling; extracellular matrix organization and biogenesis; hair follicle development; MAPKKK cascade; negative chemotaxis; negative regulation of phosphatidylinositol biosynthetic process; organ morphogenesis; phosphoinositide-mediated signaling; platelet degranulation; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of fibroblast proliferation; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of protein kinase B signaling cascade; regulation of actin cytoskeleton organization and biogenesis; regulation of peptidyl-tyrosine phosphorylation; regulation of phosphoinositide 3-kinase cascade; regulation of smooth muscle cell migration; response to wounding; skin development; wound healing
Reference #:  P04085 (UniProtKB)
Alt. Names/Synonyms: PDGF A-chain; PDGF subunit A; PDGF-1; PDGF-A; PDGF1; PDGFA; Platelet-derived growth factor A chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein; Platelet-derived growth factor alpha polypeptide; Platelet-derived growth factor subunit A
Gene Symbols: PDGFA
Molecular weight: 24,043 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
Select Structure to View Below

PDGFA

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S108‑p VIYEIPRsQVDPtsA
0 1 T113‑p PRsQVDPtsANFLIW
0 1 S114‑p RsQVDPtsANFLIWP
0 1 S136‑p CTGCCNTssVKCQPS
0 1 S137‑p TGCCNTssVKCQPSR
  mouse

 
S108 VIYEIPRSQVDPTSA
T113 PRSQVDPTSANFLIW
S114 RSQVDPTSANFLIWP
S136 CTGCCNTSSVKCQPS
S137 TGCCNTSSVKCQPSR
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