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Protein Page:
REN (human)

Overview
REN Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; EC 3.4.23.15; Protease; Secreted
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: extracellular region; extracellular space; lysosome; plasma membrane
Molecular Function: aspartic-type endopeptidase activity; insulin-like growth factor receptor binding; peptidase activity; receptor binding
Biological Process: angiotensin maturation; beta-amyloid metabolic process; cell maturation; drinking behavior; hormone-mediated signaling; kidney development; male gonad development; mesonephros development; protein catabolic process; proteolysis; regulation of blood pressure; regulation of MAPKKK cascade; renin-angiotensin regulation of aldosterone production; response to cAMP; response to lipopolysaccharide
Disease: Hyperuricemic Nephropathy, Familial Juvenile, 2; Renal Tubular Dysgenesis
Reference #:  P00797 (UniProtKB)
Alt. Names/Synonyms: angiotensin-forming enzyme; Angiotensinogenase; FLJ10761; HNFJ2; REN; RENI; Renin; renin precursor, renal
Gene Symbols: REN
Molecular weight: 45,057 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

REN

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S41‑p IFLKRMPsIREsLKE
0 1 S45‑p RMPsIREsLKERGVD
0 1 Y87‑p NYMDTQYyGEIGIGT
0 1 T330‑p VKCNEGPtLPDISFH
0 1 S347‑p GKEYTLTsADYVFQE
0 1 S355‑p ADYVFQEsYSSKKLC
  mouse

 
S39 IPLKKMPSVREILEE
I43 KMPSVREILEERGVD
Y85 NYLNTQYYGEIGIGT
T326 VNCSQVPTLPDISFD
S343 GRAYTLSSTDYVLQY
P351 TDYVLQYPNRRDKLC
  rat

 
S39 ILLKKMPSVREILEE
I43 KMPSVREILEERGVD
Y85 NYLDTQYYGEIGIGT
T326 VNCSQVPTLPDISFY
N343 GRTYTLSNMDYVQKN
P351 MDYVQKNPFRNDDLC
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