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Protein Page:
IL25 (human)

Overview
IL25 Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses. Belongs to the IL-17 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: extracellular region; extracellular space
Molecular Function: cytokine activity; interleukin-17E receptor binding
Biological Process: cell surface receptor linked signal transduction; eosinophil differentiation; inflammatory response; inflammatory response to antigenic stimulus; interleukin-13 production; interleukin-5 production; positive regulation of transcription from RNA polymerase II promoter; response to fungus; response to nematode
Reference #:  Q9H293 (UniProtKB)
Alt. Names/Synonyms: IL-17E; IL-25; IL17E; IL25; interleukin 17E; interleukin 25; Interleukin-17E; Interleukin-25
Gene Symbols: IL25
Molecular weight: 20,330 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
Select Structure to View Below

IL25

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S48 PSKGQDTSEELLRWS
0 1 Y92‑p RAISPWRyELDRDLN
  IL25 iso2  
S32‑p PSKGQDTsEELLRWS
Y76 RAISPWRYELDRDLN
  mouse

 
P40 PSKEQEPPEEWLKWS
Y84 RAISPWSYELDRDLN
  rat

 
P40 PSKQQEFPEEWLKWN
Y84 RAISPWSYELDRDLN
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