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Protein Page:
NKX2-2 (human)

Overview
NKX2-2 Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. Belongs to the NK-2 homeobox family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Transcription factor
Chromosomal Location of Human Ortholog: 20p11.22
Cellular Component: nucleoplasm
Molecular Function: chromatin binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; transcription factor binding
Biological Process: astrocyte differentiation; brain development; endocrine pancreas development; gut development; negative regulation of neuron differentiation; neuron fate specification; oligodendrocyte development; optic nerve development; positive regulation of neuron differentiation; positive regulation of oligodendrocyte differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; response to glucose stimulus; response to progesterone stimulus; smoothened signaling pathway; spinal cord motor neuron differentiation; spinal cord oligodendrocyte cell fate specification; transcription, DNA-dependent
Reference #:  O95096 (UniProtKB)
Alt. Names/Synonyms: Homeobox protein NK-2 homolog B; Homeobox protein Nkx-2.2; NK-2 homolog B; NK2 homeobox 2; NK2 transcription factor related, locus 2; NK2 transcription factor-like protein B; NKX2-2; NKX2.2; NKX22; NKX2B
Gene Symbols: NKX2-2
Molecular weight: 30,133 Da
Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NKX2-2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T6‑p __MSLTNtKtGFsVK
0 1 T8‑p MSLTNtKtGFsVKDI
0 1 S11‑p TNtKtGFsVKDILDL
0 1 S58‑p GALDAVQsLPLKNPF
0 2 N63 VQsLPLKNPFYDSSD
0 1 S199‑p MEVTPLPsPRRVAVP
  mouse

 
T6 __MSLTNTKTGFSVK
T8 MSLTNTKTGFSVKDI
S11 TNTKTGFSVKDILDL
S58 GALDAVQSLPLKsPF
S63‑p VQSLPLKsPFYDSSD
S199 MEVTPLPSPRRVAVP
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