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Protein Page:
NMDAR1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NMDAR1 a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: cell surface; dendrite; dendritic spine; excitatory synapse; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; synaptic vesicle; terminal button
Molecular Function: calcium channel activity; calcium ion binding; calmodulin binding; glutamate binding; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; neurotransmitter binding; protein binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: calcium ion homeostasis; cation transport; ephrin receptor signaling pathway; ionotropic glutamate receptor signaling pathway; MAPKKK cascade; positive regulation of transcription from RNA polymerase II promoter; propylene metabolic process; regulation of excitatory postsynaptic membrane potential; regulation of membrane potential; response to ethanol; synaptic transmission; visual learning
Disease: Mental Retardation, Autosomal Dominant 8
Reference #:  Q05586 (UniProtKB)
Alt. Names/Synonyms: glutamate [NMDA] receptor subunit zeta 1; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; GRIN1; N-methyl-D-aspartate receptor channel, subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1; NMDA1; NMDAR1; NMDZ1; NR1
Gene Symbols: GRIN1
Molecular weight: 105,373 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NMDAR1

Protein Structure Not Found.
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Download ChimeraX Script


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Sites Implicated In
molecular association, regulation: Y837‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K51‑ac EAVNQANkRHGSWKI
0 9 - gap
0 2 - gap
0 1 T317 GNTNIWKTGPLFKRV
0 1 T386 IIWPGGETEKPRGYQ
0 1 T683‑p SDKFIYAtVKQSSVD
1 0 Y837‑p LIFIEIAyKRHKDAR
0 1 K860 AAVNVWRKNLQDRKS
1 0 T879 PDPKKKATFRAITST
4 1 S889 AITSTLASsFKRRRs
12 5 S890‑p ITSTLASsFKRRRss
21 0 S896‑p SsFKRRRssKDtstG
26 0 S897‑p sFKRRRssKDtstGG
0 1 - gap
0 2 - gap
1 1 T900‑p RRRssKDtstGGGRG
0 1 S901‑p RRssKDtstGGGRGA
0 1 T902‑p RssKDtstGGGRGAL
0 1 K913 RGALQNQKDTVLPRR
3381 : Phospho-NMDAR1 (Ser890) Antibody
3384 : Phospho-NMDAR1 (Ser896) Antibody
3385 : Phospho-NMDAR1 (Ser897) Antibody
  NMDAR1 iso2  
K51 EAVNQANKRHGSWKI
- gap
- gap
T317 GNTNIWKTGPLFKRV
T386 IIWPGGETEKPRGYQ
T683 SDKFIYATVKQSSVD
Y837 LIFIEIAYKRHKDAR
K860 AAVNVWRKNLQQYHP
- gap
- gap
- gap
- gap
- gap
Y865 WRKNLQQYHPTDITG
S877 ITGPLNLSDPSVSTV
- gap
- gap
- gap
- gap
  NMDAR1 iso5  
K51 EAVNQANKRHGSWKI
Y196‑p SKSKKRNyENLDQLs
S203‑p yENLDQLsYDNKRGP
T338 GNTNIWKTGPLFKRV
T407 IIWPGGETEKPRGYQ
T704 SDKFIYATVKQSSVD
Y858 LIFIEIAYKRHKDAR
K881 AAVNVWRKNLQDRKS
T900 PDPKKKATFRAITST
S910 AITSTLASSFKRRRS
S911 ITSTLASSFKRRRSS
S917 SSFKRRRSSKDTSTG
S918 SFKRRRSSKDTSTGG
- gap
- gap
T921 RRRSSKDTSTGGGRG
S922 RRSSKDTSTGGGRGA
T923 RSSKDTSTGGGRGAL
K934 RGALQNQKDTVLPRR
  mouse

► Hide Isoforms
 
K51 EAVNQANKRHGSWKI
- gap
- gap
T317‑p GNTNIWKtGPLFKRV
T386‑p IIWPGGEtEKPRGYQ
T683 SDKFIYATVKQSSVD
Y837 LIFIEIAYKRHKDAR
K860 AAVNVWRKNLQDRKS
T879 PDPKKKATFRAITST
S889‑p AITSTLAssFKRRRs
S890‑p ITSTLAssFKRRRss
S896‑p ssFKRRRssKDTSTG
S897‑p sFKRRRssKDTSTGG
- gap
- gap
T900 RRRssKDTSTGGGRG
S901 RRssKDTSTGGGRGA
T902 RssKDTSTGGGRGAL
K913‑ub RGALQNQkDTVLPRR
  NMDAR1 iso2  
K51 EAVNQANKRHGSWKI
- gap
- gap
T317 GNTNIWKTGPLFKRV
T386 IIWPGGETEKPRGYQ
T683 SDKFIYATVKQSSVD
Y837 LIFIEIAYKRHKDAR
K860‑ub AAVNVWRkNLQQYHP
- gap
- gap
- gap
- gap
- gap
Y865 WRkNLQQYHPTDITG
S877‑p ITGPLNLsDPSVSTV
- gap
- gap
- gap
- gap
  NMDAR1 iso3  
K51 EAVNQANKRHGSWKI
Y196‑p SKSKKRNyENLDQLs
S203‑p yENLDQLsYDNKRGP
T338 GNTNIWKTGPLFKRV
T407 IIWPGGETEKPRGYQ
T704 SDKFIYATVKQSSVD
Y858 LIFIEIAYKRHKDAR
K881 AAVNVWRKNLQDRKS
T900 PDPKKKATFRAITST
S910 AITSTLASSFKRRRS
S911 ITSTLASSFKRRRSS
S917 SSFKRRRSSKDTQyH
S918 SFKRRRSSKDTQyHP
Y923‑p RSSKDTQyHPTDITG
S935 ITGPLNLSDPSVSTV
- gap
- gap
- gap
- gap
  rat

► Hide Isoforms
 
K51 EAVNQANKRHGSWKI
- gap
- gap
T317 GNTNIWKTGPLFKRV
T386 IIWPGGETEKPRGYQ
T683 SDKFIYATVKQSSVD
Y837 LIFIEIAYKRHKDAR
K860 AAVNVWRKNLQDRKS
T879‑p PDPKKKAtFRAITST
S889‑p AITSTLAssFKRRRs
S890‑p ITSTLAssFKRRRss
S896‑p ssFKRRRssKDtSTG
S897‑p sFKRRRssKDtSTGG
- gap
- gap
T900‑p RRRssKDtSTGGGRG
S901 RRssKDtSTGGGRGA
T902 RssKDtSTGGGRGAL
K913 RGALQNQKDTVLPRR
  NMDAR1 iso7  
K51 EAVNQANKRHGSWKI
Y196 SKSKKRNYENLDQLS
S203 YENLDQLSYDNKRGP
T338 GNTNIWKTGPLFKRV
T407 IIWPGGETEKPRGYQ
T704 SDKFIYATVKQSSVD
Y858 LIFIEIAYKRHKDAR
K881 AAVNVWRKNLQQYHP
- gap
- gap
- gap
- gap
- gap
Y886 WRKNLQQYHPTDITG
S898‑p ITGPLNLsDPSVSTV
- gap
- gap
- gap
- gap
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