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Protein Page:
SIRT5 (human)

Overview
SIRT5 NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD- dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro. Belongs to the sirtuin family. Class III subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC 3.5.1.-; Mitochondrial
Chromosomal Location of Human Ortholog: 6p23
Cellular Component: cytosol; mitochondrial intermembrane space; mitochondrial matrix; mitochondrion; nucleus
Molecular Function: NAD+ ADP-ribosyltransferase activity; zinc ion binding
Biological Process: chromatin silencing; protein amino acid ADP-ribosylation; protein amino acid deacetylation
Reference #:  Q9NXA8 (UniProtKB)
Alt. Names/Synonyms: FLJ36950; NAD-dependent deacetylase sirtuin-5; silent mating type information regulation 2, S.cerevisiae, homolog 5; sir2-like 5; SIR2-like protein 5; SIR2L5; SIRT5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae); sirtuin type 5
Gene Symbols: SIRT5
Molecular weight: 33,881 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SIRT5

Protein Structure Not Found.
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