a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, STE; EC 126.96.36.199; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Molecular Function: ATP binding; enzyme binding; JUN kinase kinase activity; magnesium ion binding; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity
Biological Process: activation of JNK activity; apoptosis; innate immune response; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of neuron apoptosis; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; regulation of apoptosis; regulation of mitotic cell cycle; response to heat; response to osmotic stress; response to UV; response to wounding; signal transduction; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.