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Protein Page:
MKK7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MKK7 a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, STE; EC 2.7.12.2; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 19p13.3-p13.2
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: ATP binding; enzyme binding; JUN kinase kinase activity; magnesium ion binding; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity
Biological Process: activation of JNK activity; apoptosis; innate immune response; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of neuron apoptosis; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; regulation of apoptosis; regulation of mitotic cell cycle; response to heat; response to osmotic stress; response to UV; response to wounding; signal transduction; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
Reference #:  O14733 (UniProtKB)
Alt. Names/Synonyms: c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK 2; JNKK2; MAP kinase kinase 7; MAP2K7; MAPK/ERK kinase 7; MAPKK 7; MAPKK7; MEK 7; MEK7; mitogen-activated protein kinase kinase 7; MKK7; MP2K7; PRKMK7
Gene Symbols: MAP2K7
Molecular weight: 47,485 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Parkinson's Disease  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MKK7

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S271‑p, T275‑p
enzymatic activity, induced: S271‑p, T275‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K9‑ub AASSLEQkLSRLEAK
0 4 S35‑p IDLNLDIsPQRPRPT
0 1 S55‑p ANDGGSRsPSSESsP
0 1 S61‑p RsPSSESsPQHPtPP
1 5 T66‑p ESsPQHPtPPARPRH
0 1 S79‑p RHMLGLPsTLFtPRs
1 15 T83‑p GLPsTLFtPRsMEsI
0 2 S86‑p sTLFtPRsMEsIEID
0 1 S89‑p FtPRsMEsIEIDQkL
0 1 K95‑ub EsIEIDQkLQEIMKQ
0 1 T142‑p WKMRFRKtGHVIAVK
0 2 K245‑ub GVIHRDVkPSNILLD
3 2 S271‑p ISGRLVDsKAKtRsA
2 1 T275‑p LVDsKAKtRsAGCAA
0 2 S277‑p DsKAKtRsAGCAAyM
0 1 Y283‑p RsAGCAAyMAPERID
0 1 K326 QFPYKNCKTDFEVLT
0 1 K373‑ub RKRPKYNkLLEHsFI
0 1 S378‑p YNkLLEHsFIKRYET
0 2 T401‑p FKDVMAKtEsPRtsG
0 3 S403‑p DVMAKtEsPRtsGVL
0 1 T406‑p AKtEsPRtsGVLsQP
0 1 S407‑p KtEsPRtsGVLsQPH
0 2 S411‑p PRtsGVLsQPHLPFF
0 1 - gap
4171 : Phospho-MKK7 (Ser271/Thr275) Antibody
4171 : Phospho-MKK7 (Ser271/Thr275) Antibody
  mouse

► Hide Isoforms
 
K9‑ub AASSLEQkLSRLEAK
S35 IDLNLDISPQRPRPI
S71 ANDGGSRSPSSESSP
S77 RSPSSESSPQHPtPP
T82‑p ESSPQHPtPPTRPRH
S95 RHMLGLPSTLFTPRS
T99 GLPSTLFTPRSMESI
S102 STLFTPRSMESIEID
S105 FTPRSMESIEIDQKL
K111 ESIEIDQKLQEIMKQ
T158 WKMRFRKTGHIIAVK
K261 GVIHRDVKPSNILLD
S287‑p ISGRLVDsKAKtRSA
T291‑p LVDsKAKtRSAGCAA
S293 DsKAKtRSAGCAAYM
Y299 RSAGCAAYMAPERID
K342‑ub QFPYKNCkTDFEVLT
K389 RKRPKYNKLLEHSFI
S394 YNKLLEHSFIKHYEI
T417 FKDVMAKTESPRTSG
S419 DVMAKTESPRTSGVL
T422 AKTESPRTSGVLSQH
S423 KTESPRTSGVLSQHH
S427 PRTSGVLSQHHLPFF
S464‑p RCRGRVPsPRRATGG
4171 : Phospho-MKK7 (Ser271/Thr275) Antibody
4171 : Phospho-MKK7 (Ser271/Thr275) Antibody
  MKK7 iso2  
K9 AASSLEQKLSRLEAK
S35‑p IDLNLDIsPQRPRPT
S55 ANDGGSRSPSSESSP
S61 RSPSSESSPQHPtPP
T66‑p ESSPQHPtPPTRPRH
S79 RHMLGLPSTLFtPRS
T83‑p GLPSTLFtPRSMESI
S86 STLFtPRSMESIEID
S89 FtPRSMESIEIDQKL
K95 ESIEIDQKLQEIMKQ
T142 WKMRFRKTGHIIAVK
K245 GVIHRDVKPSNILLD
S271 ISGRLVDSKAKTRSA
T275 LVDSKAKTRSAGCAA
S277 DSKAKTRSAGCAAYM
Y283 RSAGCAAYMAPERID
K326 QFPYKNCKTDFEVLT
K373 RKRPKYNKLLEHSFI
S378 YNKLLEHSFIKHYEI
T401 FKDVMAKTEsPRTSG
S403‑p DVMAKTEsPRTSGVL
T406 AKTEsPRTSGVLSQH
S407 KTEsPRTSGVLSQHH
S411 PRTSGVLSQHHLPFF
- gap
  MKK7 iso6  
K9 AASSLEQKLSRLEAK
S35 IDLNLDISPQRPRPI
S71 ANDGGSRSPSSESSP
S77 RSPSSESSPQHPTPP
T82 ESSPQHPTPPTRPRH
S95 RHMLGLPSTLFTPRS
T99 GLPSTLFTPRSMESI
S102 STLFTPRSMESIEID
S105 FTPRSMESIEIDQKL
K111 ESIEIDQKLQEIMKQ
T158 WKMRFRKTGHIIAVK
K261 GVIHRDVKPSNILLD
S287 ISGRLVDSKAKTRSA
T291 LVDSKAKTRSAGCAA
S293 DSKAKTRSAGCAAYM
Y299 RSAGCAAYMAPERID
K342 QFPYKNCKTDFEVLT
K389 RKRPKYNKLLEHSFI
S394 YNKLLEHSFIKHYEI
T417 FKDVMAKTEsPRTSG
S419‑p DVMAKTEsPRTSGVL
T422 AKTEsPRTSGVLSQH
S423 KTEsPRTSGVLSQHH
S427 PRTSGVLSQHHLPFF
- gap
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