Curated Information
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Curated Information Page
PubMed Id: 19706600 
Fan Y, et al. (2009) Tumor necrosis factor-alpha induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation. J Biol Chem 284, 29290-7 19706600
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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K195-ub - NFkB-p65 (human)
Orthologous residues
NFkB‑p65 (human): K195‑ub, NFkB‑p65 (mouse): K195‑ub, NFkB‑p65 (rat): K195‑ub
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial), MEF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
Downstream Regulation
 Effect of modification (function):  activity, inhibited, protein degradation
 Effect of modification (process):  transcription, altered
 Comments:  TNF alpha - induced RelA polyubiquitination and degradation


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