Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 19706513 
Daniel AR, Lange CA (2009) Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells. Proc Natl Acad Sci U S A 106, 14287-92 19706513
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S294-p - PR (human)
Orthologous residues
PR (human): S294‑p, PR iso2 (human): S130‑p, PR (mouse): S294‑p, PR (rat): S293‑p, PR (chicken):
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  HeLa (cervical), T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK2 (human) transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (function):  sumoylation
 Effect of modification (process):  transcription, induced
 Comments:  inhibits sumoylation of PR K388

K388-sm - PR (human)
Orthologous residues
PR (human): K388‑sm, PR iso2 (human): K224‑sm, PR (mouse): K386‑sm, PR (rat): K387‑sm, PR (chicken): K294‑sm
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  HeLa (cervical), T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
progestin R5020 increase
Downstream Regulation
 Effect of modification (process):  cell growth, altered, transcription, inhibited
 Comments:  represses basal proliferation of breast cancer cells


Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.