Curated Information
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Curated Information Page
PubMed Id: 19652227 
Uchida Y, et al. (2009) Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32. J Biol Chem 284, 27393-401 19652227
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y32-p - CRMP-2 (mouse)
Orthologous residues
CRMP‑2 (human): Y32‑p, CRMP‑2 iso3 (human): Y137‑p, CRMP‑2 (mouse): Y32‑p, CRMP‑2 (rat): Y32‑p, CRMP‑2 (chicken): Y32‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, brainstem', 'brain, cerebellum', spinal cord
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SEMA3A (human) increase

Y32-p - CRMP-2 (rat)
Orthologous residues
CRMP‑2 (human): Y32‑p, CRMP‑2 iso3 (human): Y137‑p, CRMP‑2 (mouse): Y32‑p, CRMP‑2 (rat): Y32‑p, CRMP‑2 (chicken): Y32‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Fes (human) transfection of constitutively active enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SEMA3A (human) increase

Y32-p - CRMP-4 (rat)
Orthologous residues
CRMP‑4 (human): Y32‑p, CRMP‑4 iso3 (human): Y146‑p, CRMP‑4 (mouse): Y32‑p, CRMP‑4 iso3 (mouse): Y145‑p, CRMP‑4 (rat): Y32‑p, CRMP‑4 iso2 (rat): Y145‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (human)


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