Curated Information

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Curated Information Page

PubMed Id: 19652227

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Uchida Y, et al. (2009) Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32. J Biol Chem 284, 27393-401 19652227

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y32-p - CRMP-2 (mouse)

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Orthologous residues

CRMP‑2 (human): Y32‑p, CRMP‑2 iso3 (human): Y137‑p, CRMP‑2 (mouse): Y32‑p, CRMP‑2 (rat): Y32‑p, CRMP‑2 (chicken): Y32‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'brain, brainstem', 'brain, cerebellum', spinal cord

Cellular systems studied: tissue

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
		SEMA3A (human)		increase

Y32-p - CRMP-2 (rat)

▲

Orthologous residues

CRMP‑2 (human): Y32‑p, CRMP‑2 iso3 (human): Y137‑p, CRMP‑2 (mouse): Y32‑p, CRMP‑2 (rat): Y32‑p, CRMP‑2 (chicken): Y32‑p

Characterization

Methods used to characterize site in vivo: immunoprecipitation, mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 293T (epithelial)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	Fyn (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	Fes (human)	transfection of constitutively active enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
		SEMA3A (human)		increase

Y32-p - CRMP-4 (rat)

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Orthologous residues

CRMP‑4 (human): Y32‑p, CRMP‑4 iso3 (human): Y146‑p, CRMP‑4 (mouse): Y32‑p, CRMP‑4 iso3 (mouse): Y145‑p, CRMP‑4 (rat): Y32‑p

Characterization

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	Fyn (human)

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