Curated Information
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Curated Information Page
PubMed Id: 19622773 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Fan S, et al. (2009) Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner. Cancer Res 69, 6083-91 19622773
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1387-p - BRCA1 (human) ▲
Orthologous residues
BRCA1 (human): S1387‑p, BRCA1 iso6 (human): S284‑p, BRCA1 (mouse): S1343‑p, BRCA1 (rat): S1344‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioma, breast cancer
 Relevant cell lines - cell types - tissues:  MDA-MB231 (breast cell), T47D (breast cell), U87MG (glial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) siRNA inhibition of enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DIM increase

S1423-p - BRCA1 (human) ▲
Orthologous residues
BRCA1 (human): S1423‑p, BRCA1 iso6 (human): S320‑p, BRCA1 (mouse): N1379‑p, BRCA1 (rat): S1380‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioma, breast cancer
 Relevant cell lines - cell types - tissues:  MDA-MB231 (breast cell), T47D (breast cell), U87MG (glial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DIM no change compared to control

S1457-p - BRCA1 (human) ▲
Orthologous residues
BRCA1 (human): S1457‑p, BRCA1 iso6 (human): S353‑p, BRCA1 (mouse): S1413‑p, BRCA1 (rat): S1414‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioma, breast cancer
 Relevant cell lines - cell types - tissues:  MDA-MB231 (breast cell), T47D (breast cell), U87MG (glial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DIM no change compared to control

S1524-p - BRCA1 (human) ▲
Orthologous residues
BRCA1 (human): S1524‑p, BRCA1 iso6 (human): S420‑p, BRCA1 (mouse): S1481‑p, BRCA1 (rat): S1482‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioma, breast cancer
 Relevant cell lines - cell types - tissues:  MDA-MB231 (breast cell), T47D (breast cell), U87MG (glial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DIM increase


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