Curated Information
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Curated Information Page
PubMed Id: 17965024 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Liu YV, et al. (2007) Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. J Biol Chem 282, 37064-73 17965024
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S146-p - RACK1 (human) ▲
Orthologous residues
RACK1 (human): S146‑p, RACK1 (mouse): S146‑p, RACK1 (rat): S146‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  protein conformation
 Comments:  S146 phosphoirylation promotes dimerization of RACK1 and degredation of HIF-1 alpha.


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