Curated Information
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Curated Information Page
PubMed Id: 19509291 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Tashiro K, et al. (2009) GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling. J Biol Chem 284, 20206-14 19509291
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y105-p - GAREM (human) ▲
Orthologous residues
GAREM (human): Y105‑p, GAREM iso3 (human): Y105‑p, GAREM (mouse): Y105‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  COS (fibroblast), HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Grb2 (human) SH3 Induces co-immunoprecipitation
 Comments:  activates Erk

Y453-p - GAREM (human) ▲
Orthologous residues
GAREM (human): Y453‑p, GAREM iso3 (human): Y453‑p, GAREM (mouse): Y453‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  COS (fibroblast), HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell growth, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Grb2 (human) SH3 Induces co-immunoprecipitation
SHP-2 (human) Induces enzymatic activity, induced co-immunoprecipitation


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