Curated Information

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Curated Information Page

PubMed Id: 17233759

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Gomes AR, et al. (2007) PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression. Traffic 8, 259-69 17233759

S862-p - GluR4 (rat)

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Orthologous residues

GluR4 (human): S862‑p, GluR4 iso2 (human): ‑, GluR4 (mouse): S862‑p, GluR4 iso2 (mouse): S862‑p, GluR4 (rat): S862‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 'brain, hippocampus', 293 (epithelial), retina

Cellular systems studied: cell lines, primary cells, tissue

Species studied: chicken, human, rat

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	PKACa (human)	phospho-antibody, pharmacological activator of upstream enzyme
KINASE	PKCG (human)	phospho-antibody, mutation in upstream enzyme recognition motif, co-immunoprecipitation, pharmacological activator of upstream enzyme, transfection of wild-type enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
phorbol ester				increase
forskolin				increase

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