Uemura K, et al. (2007) GSK3beta activity modifies the localization and function of presenilin 1. J Biol Chem 282, 15823-32 17389597

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S353-p - PSEN1 (human) ▲

Modsite: sHLGPHRstPEsRAA SwissProt Entrez-Gene Orthologous residues PSEN1 (human): S353‑p, PSEN1 iso2 (human): S349‑p, PSEN1 iso3 (human): ‑, PSEN1 (mouse): S353‑p, PSEN1 (rat): S354‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE GSK3B (human) transfection of constitutively active enzyme Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CDH2 (human) Disrupts co-immunoprecipitation CTNNB1 (human) Disrupts co-immunoprecipitation Comments:  reduced interaction was observed in the constitutively active GSK3beta (S9A) mutant; GSK3beta activation downregulates PI3K/Akt signaling probably by reducing the interaction of PSEN1 with N-cadherin (CDH2)/ beta catenin (CTNNB1);

S357-p - PSEN1 (human) ▲

Modsite: PHRstPEsRAAVQEL SwissProt Entrez-Gene Orthologous residues PSEN1 (human): S357‑p, PSEN1 iso2 (human): S353‑p, PSEN1 iso3 (human): ‑, PSEN1 (mouse): S357‑p, PSEN1 (rat): S358‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE GSK3B (human) transfection of constitutively active enzyme Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CDH2 (human) Disrupts co-immunoprecipitation CTNNB1 (human) Disrupts co-immunoprecipitation Comments:  reduced interaction was observed in the constitutively active GSK3beta (S9A) mutant; GSK3beta activation downregulates PI3K/Akt signaling probably by reducing the interaction of PSEN1 with N-cadherin (CDH2)/ beta catenin (CTNNB1);