Curated Information
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PubMed Id: 17389597 
Uemura K, et al. (2007) GSK3beta activity modifies the localization and function of presenilin 1. J Biol Chem 282, 15823-32 17389597
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S353-p - PSEN1 (human)
Orthologous residues
PSEN1 (human): S353‑p, PSEN1 iso3 (human): , PSEN1 (mouse): S353‑p, PSEN1 (rat): S354‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CDH2 (human) Disrupts co-immunoprecipitation
CTNNB1 (human) Disrupts co-immunoprecipitation
 Comments:  reduced interaction was observed in the constitutively active GSK3beta (S9A) mutant; GSK3beta activation downregulates PI3K/Akt signaling probably by reducing the interaction of PSEN1 with N-cadherin (CDH2)/ beta catenin (CTNNB1);

S357-p - PSEN1 (human)
Orthologous residues
PSEN1 (human): S357‑p, PSEN1 iso3 (human): , PSEN1 (mouse): S357‑p, PSEN1 (rat): S358‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GSK3B (human) transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CTNNB1 (human) Disrupts co-immunoprecipitation
CDH2 (human) Disrupts co-immunoprecipitation
 Comments:  reduced interaction was observed in the constitutively active GSK3beta (S9A) mutant; GSK3beta activation downregulates PI3K/Akt signaling probably by reducing the interaction of PSEN1 with N-cadherin (CDH2)/ beta catenin (CTNNB1);


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