Curated Information
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Curated Information Page
PubMed Id: 17294403 
Wabnitz GH, et al. (2007) Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25. Eur J Immunol 37, 649-62 17294403
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S5-p - L-plastin (human)
Orthologous residues
L‑plastin (human): S5‑p, L‑plastin (mouse): S5‑p, L‑plastin (rat): S5‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  Raji (B lymphocyte), T lymphocyte-blood
 Cellular systems studied:  primary cultured cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3/CD28 increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  increases expression, and stimulates trafficking to the cell surface, of CD25 and CD69


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