Curated Information
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Curated Information Page
PubMed Id: 17339478 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Schmitter T, et al. (2007) The granulocyte receptor carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) directly associates with Vav to promote phagocytosis of human pathogens. J Immunol 178, 3797-805 17339478
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Y230-p - CEACAM3 (human)
Orthologous residues
CEACAM3 (human): Y230‑p, CEACAM3 (mouse): , CEACAM3 (rat):
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
VAV1 (human) Induces pull-down assay, in vitro
 Comments:  specific interaction between SH2 domain of VAV1 and ITAM-like sequence of CEACAM3; Vav1 required for CEACAM3-mediated phagocytosis of bacterial pathogens


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