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Orthologous residues
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CEACAM3 (human): Y230‑p, CEACAM3 (mouse): ‑, CEACAM3 (rat): ‑
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site
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Relevant cell lines - cell types - tissues:
293 (epithelial)
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Cellular systems studied:
cell lines
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Species studied:
human
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Downstream Regulation
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Effect of modification (function):
molecular association, regulation
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Modification regulates interactions with:
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Interacting molecule
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Interacting domains
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Effect
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Consequences (function)
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Consequences (process)
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Detection assays
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VAV1 (human)
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Induces
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pull-down assay, in vitro
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Comments:
specific interaction between SH2 domain of VAV1 and ITAM-like sequence of CEACAM3; Vav1 required for CEACAM3-mediated phagocytosis of bacterial pathogens
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