Curated Information
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Curated Information Page
PubMed Id: 19412162 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Santra MK, Wajapeyee N, Green MR (2009) F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. Nature 459, 722-5 19412162
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1981-p - ATM (human)
Orthologous residues
ATM (human): S1981‑p, ATM (mouse): S1987‑p, ATM (rat): S1988‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  SK-MEL28 (melanocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

T286-p - CCND1 (human)
Orthologous residues
CCND1 (human): T286‑p, CCND1 (mouse): T286‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  SK-MEL28 (melanocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FBXO31 (human) Induces cell cycle regulation co-immunoprecipitation

S278-p - FBXO31 (human)
Orthologous residues
FBXO31 (human): S278‑p, FBXO31 (mouse): S264‑p, FBXO31 (rat): S264‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  SK-MEL28 (melanocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATM (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (human) co-immunoprecipitation, mutation in upstream enzyme recognition motif, transfection of inactive enzyme, activation of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
 Effect of modification (function):  protein stabilization


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