Curated Information
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Curated Information Page
PubMed Id: 19565571 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Wu H, Symes K, Seldin DC, Dominguez I (2009) Threonine 393 of beta-catenin regulates interaction with Axin. J Cell Biochem 108, 52-63 19565571
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S33-p - CTNNB1 (human)
Orthologous residues
CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  C57MG (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTNNB1 (human) decrease decreased by CTNNB1 T393 phosphorylation

S37-p - CTNNB1 (human)
Orthologous residues
CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  C57MG (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTNNB1 (human) decrease decreased by CTNNB1 T393 phosphorylation

T41-p - CTNNB1 (human)
Orthologous residues
CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  C57MG (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTNNB1 (human) decrease decreased by CTNNB1 T393 phosphorylation

T393-p - CTNNB1 (human)
Orthologous residues
CTNNB1 (human): T393‑p, CTNNB1 (mouse): T393‑p, CTNNB1 (rat): T393‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial), C57MG (epithelial), oocyte
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  frog, human, mouse
Downstream Regulation
 Effect of modification (function):  activity, induced, molecular association, regulation, phosphorylation, protein stabilization
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
axin 1 (human) Disrupts in vitro
 Comments:  decreases phosphorylation of CTNNB1 S33/S37/T41


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