Curated Information
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Curated Information Page
PubMed Id: 17329249 
Jones BW, Song GJ, Greuber EK, Hinkle PM (2007) Phosphorylation of the endogenous thyrotropin-releasing hormone receptor in pituitary GH3 cells and pituitary tissue revealed by phosphosite-specific antibodies. J Biol Chem 282, 12893-906 17329249
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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T365-p - TRHR (rat)
Orthologous residues
TRHR (human): T365‑p, TRHR (mouse): T365‑p, TRHR (rat): T365‑p
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, phospho-antibody
 Cellular systems studied:  cell lines, tissue
 Species studied:  hamster, human, rat
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE GRK2 (human) transfection of dominant-negative enzyme, antisense inhibition of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionomycin, phorbol ester increase
TRH increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, receptor internalization, altered

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