Curated Information

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PubMed Id: 17301055

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Taguchi N, et al. (2007) Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem 282, 11521-9 17301055

S635-p - DRP1 (rat)

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Orthologous residues

DRP1 (human): S616‑p, DRP1 iso3 (human): S579‑p, DRP1 (mouse): S622‑p, DRP1 iso3 (mouse): S579‑p, DRP1 iso6 (mouse): S592‑p, DRP1 (rat): S635‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site

Relevant cell lines - cell types - tissues: HeLa (cervical)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	CDK1 (human)

Downstream Regulation

Effect of modification (process): cell cycle regulation

Comments: promotes mitochondrial fission in mitosis

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