Curated Information
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Curated Information Page
PubMed Id: 8206937 
Favre B, Zolnierowicz S, Turowski P, Hemmings BA (1994) The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. J Biol Chem 269, 16311-7 8206937
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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L309-me - PPP2CA (human)
Orthologous residues
PPP2CA (human): L309‑me, PPP2CA iso2 (human): L255‑me, PPP2CA (mouse): L309‑me, PPP2CA (rat): L309‑me, PPP2CA (pig): L309‑me
 Methods used to characterize site in vivo 2D analysis, electrophoretic mobility shift, peptide sequencing, western blotting
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  biosynthetic labeling [3H]AdoMet, antibody sensitivity changes upon modification
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PAN increase
ethanol decrease
acetone decrease
freeze/thaw decrease
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

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