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Orthologous residues
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PPP2CA (human): L309‑m, PPP2CA (mouse): L309‑m, PPP2CA (rat): L309‑m
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Characterization
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Methods used to characterize site in vivo:
2D analysis, electrophoretic mobility shift, peptide sequencing, western blotting
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Disease tissue studied:
breast cancer
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Relevant cell lines - cell types - tissues:
MCF-7 (breast cell)
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Cellular systems studied:
cell lines
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Species studied:
human
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Comments:
biosynthetic labeling [3H]AdoMet, antibody sensitivity changes upon modification
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Upstream Regulation
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Treatments, proteins and their effect on site modification:
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Treatments
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Referenced Treatments
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Manipulated Protein
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Referenced Protein
|
Effect
|
Notes
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PAN
|
|
|
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increase
|
|
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ethanol
|
|
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decrease
|
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acetone
|
|
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decrease
|
|
|
freeze/thaw
|
|
|
|
decrease
|
|
|
|
Downstream Regulation
|
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Effect of modification (function):
enzymatic activity, induced
|
