Curated Information
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Curated Information Page
PubMed Id: 17218258 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Baumann C, K├Ârner R, Hofmann K, Nigg EA (2007) PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell 128, 101-14 17218258
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T1063-p - PICH (human)
Orthologous residues
PICH (human): T1063‑p, PICH (mouse): T1057‑p, PICH (rat): T1048‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical), U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK1 (human)
KINASE PLK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PLK1 (human) transfection of constitutively active enzyme, transfection of inactive enzyme, co-immunoprecipitation, antisense inhibition of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
siRNA decrease
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  required for checkpoint signaling and proper sister chromosomes segregation


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