Curated Information
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Curated Information Page
PubMed Id: 17060449 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Mori D, et al. (2007) NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol 27, 352-67 17060449
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S558-p - TACC3 (human) ▲
Orthologous residues
TACC3 (human): S558‑p, TACC3 (mouse): S347‑p

S198-p - NDEL1 (mouse) ▲
Orthologous residues
NDEL1 (human): S198‑p, NDEL1 (mouse): S198‑p, NDEL1 (rat): S198‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK5 (human)

T219-p - NDEL1 (mouse) ▲
Orthologous residues
NDEL1 (human): T219‑p, NDEL1 (mouse): T219‑p, NDEL1 (rat): T219‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  MEF (fibroblast) [IGF1R (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK5 (human)

S231-p - NDEL1 (mouse) ▲
Orthologous residues
NDEL1 (human): S231‑p, NDEL1 (mouse): S231‑p, NDEL1 (rat): S231‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry
 Relevant cell lines - cell types - tissues:  MEF (fibroblast) [IGF1R (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK5 (human)

S251-p - NDEL1 (mouse) ▲
Orthologous residues
NDEL1 (human): S251‑p, NDEL1 (mouse): S251‑p, NDEL1 (rat): S251‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, phospho-antibody
 Relevant cell lines - cell types - tissues:  MEF (fibroblast) [IGF1R (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE AurA (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AurA (human) co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MG132 increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  important for centrosome separation during mitosis


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