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PubMed Id: 12019309

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Zhu Y, et al. (2002) Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage. J Neurosci 22, 3898-909 12019309

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S112-p - BAD (mouse)

▲

Orthologous residues

BAD (human): S75‑p, BAD (mouse): S112‑p, BAD (rat): S113‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'brain, striatum'

Cellular systems studied: tissue

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
TGF-beta				increase

T203-p - ERK1 (mouse)

▲

Orthologous residues

ERK1 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'brain, striatum'

Cellular systems studied: tissue

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
TGF-beta				increase
TGF-beta				increase

T183-p - ERK2 (mouse)

▲

Orthologous residues

ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'brain, striatum'

Cellular systems studied: tissue

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
TGF-beta				increase

Y185-p - ERK2 (mouse)

▲

Orthologous residues

ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'brain, striatum'

Cellular systems studied: tissue

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
TGF-beta				increase

T348-p - p90RSK (mouse)

▲

Orthologous residues

p90RSK (human): T359‑p, p90RSK iso3 (human): T368‑p, p90RSK (mouse): T348‑p, p90RSK iso3 (mouse): ‑, p90RSK (rat): T359‑p, p90RSK (chicken): T377‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'brain, striatum'

Cellular systems studied: tissue

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
TGF-beta				increase

S352-p - p90RSK (mouse)

▲

Orthologous residues

p90RSK (human): S363‑p, p90RSK iso3 (human): S372‑p, p90RSK (mouse): S352‑p, p90RSK iso3 (mouse): ‑, p90RSK (rat): S363‑p, p90RSK (chicken): S381‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'brain, striatum'

Cellular systems studied: tissue

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
TGF-beta				increase

S113-p - BAD (rat)

▲

Orthologous residues

BAD (human): S75‑p, BAD (mouse): S112‑p, BAD (rat): S113‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: rat

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Effect
TGF-beta		increase
U0126		decrease
U0126	TGF-beta	inhibit treatment-induced increase

T203-p - ERK1 (rat)

▲

Orthologous residues

ERK1 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: rat

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Effect
TGF-beta		increase
U0126		decrease
U0126	TGF-beta	inhibit treatment-induced increase

Y205-p - ERK1 (rat)

▲

Orthologous residues

ERK1 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: rat

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Effect
TGF-beta		increase
U0126		decrease
U0126	TGF-beta	inhibit treatment-induced increase

T183-p - ERK2 (rat)

▲

Orthologous residues

ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: rat

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Effect
TGF-beta		increase
U0126		decrease
U0126	TGF-beta	inhibit treatment-induced increase

Y185-p - ERK2 (rat)

▲

Orthologous residues

ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: rat

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Effect
TGF-beta		increase
U0126		decrease
U0126	TGF-beta	inhibit treatment-induced increase

T359-p - p90RSK (rat)

▲

Orthologous residues

p90RSK (human): T359‑p, p90RSK iso3 (human): T368‑p, p90RSK (mouse): T348‑p, p90RSK iso3 (mouse): ‑, p90RSK (rat): T359‑p, p90RSK (chicken): T377‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: rat

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Effect
TGF-beta		increase
U0126		decrease
U0126	TGF-beta	inhibit treatment-induced increase
TGF-beta		increase
U0126		decrease
U0126	TGF-beta	inhibit treatment-induced increase

S363-p - p90RSK (rat)

▲

Orthologous residues

p90RSK (human): S363‑p, p90RSK iso3 (human): S372‑p, p90RSK (mouse): S352‑p, p90RSK iso3 (mouse): ‑, p90RSK (rat): S363‑p, p90RSK (chicken): S381‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'neuron, hippocampal'-brain

Cellular systems studied: primary cultured cells

Species studied: rat

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Effect
TGF-beta		increase
U0126		decrease
U0126	TGF-beta	inhibit treatment-induced increase

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